Pharmacokinetics and allometric scaling of antimalarial drugs
Access Status
Open access
Authors
Senarathna, Senarathna Mudiyanselage Dona Kalyani Ganga
Date
2015Supervisor
Dr Andrew Crowe
Prof. Kevin Batty
Type
Thesis
Education Level
PhD
Metadata
Show full item recordAbstract
Allometric scaling was found as a plausible technique for dose determination in children. Permeability and P-glycoprotein efflux transport of antimalarials were determined using in-vitro Caco-2 cells. Mefloquine showed P-glycoprotein inhibition. Amodiaquine, artesunate and artemisone were not P-glycoprotein substrates or inhibitors. Methylene-blue showed some P-glycoprotein mediated efflux. Permeability was high for amodiaquine and artemisone, medium for mefloquine and artesunate and low for methylene-blue. P-glycoprotein was up-regulated when exposed to dihydroartemisinin/artemisone in combinations with amodiaquine/mefloquine.
Department
School od Pharmacy
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