Pharmacokinetics and allometric scaling of antimalarial drugs
Access Status
Open access
Date
2015Supervisor
Dr Andrew Crowe
Prof. Kevin Batty
Type
Thesis
Award
PhD
Metadata
Show full item recordSchool
School od Pharmacy
Collection
Abstract
Allometric scaling was found as a plausible technique for dose determination in children. Permeability and P-glycoprotein efflux transport of antimalarials were determined using in-vitro Caco-2 cells. Mefloquine showed P-glycoprotein inhibition. Amodiaquine, artesunate and artemisone were not P-glycoprotein substrates or inhibitors. Methylene-blue showed some P-glycoprotein mediated efflux. Permeability was high for amodiaquine and artemisone, medium for mefloquine and artesunate and low for methylene-blue. P-glycoprotein was up-regulated when exposed to dihydroartemisinin/artemisone in combinations with amodiaquine/mefloquine.
Related items
Showing items related by title, author, creator and subject.
-
Omar, Marhanis; Crowe, Andrew; Tay, C.; Hughes, Jeff (2014)Objective: There is an increasing incidence of Helicobacter pylori eradication therapy failure secondary to antibiotic resistance. In this study, we aimed to assess the P-glycoprotein expression levels among subjects who ...
-
Senarathna, Ganga; Crowe, Andrew (2015)Caco2 cells are a human adenocarcinoma cell line that forms tight junctions and are widely used to examine bidirectional drug transport as well as P-glycoprotein mediated efflux. Unfortunately Caco2 cell lines can be very ...
-
Omar, Marhanis Salihah (2013)The association between P-glycoprotein and Helicobacter pylori infection was explored. We found that P-glycoprotein expression is induced by H. pylori in the upper gastrointestinal tract and influenced by the genetic ...