Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Theses
    • View Item
    • espace Home
    • espace
    • Curtin Theses
    • View Item

    Pharmacokinetics and allometric scaling of antimalarial drugs

    235318_Senarathna S 2015.pdf (2.520Mb)
    Access Status
    Open access
    Authors
    Senarathna, Senarathna Mudiyanselage Dona Kalyani Ganga
    Date
    2015
    Supervisor
    Dr Andrew Crowe
    Prof. Kevin Batty
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    School
    School od Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/1139
    Collection
    • Curtin Theses
    Abstract

    Allometric scaling was found as a plausible technique for dose determination in children. Permeability and P-glycoprotein efflux transport of antimalarials were determined using in-vitro Caco-2 cells. Mefloquine showed P-glycoprotein inhibition. Amodiaquine, artesunate and artemisone were not P-glycoprotein substrates or inhibitors. Methylene-blue showed some P-glycoprotein mediated efflux. Permeability was high for amodiaquine and artemisone, medium for mefloquine and artesunate and low for methylene-blue. P-glycoprotein was up-regulated when exposed to dihydroartemisinin/artemisone in combinations with amodiaquine/mefloquine.

    Related items

    Showing items related by title, author, creator and subject.

    • Expressions of P-glycoprotein in treatment: Resistant Helicobacter pylori patients
      Omar, Marhanis; Crowe, Andrew; Tay, C.; Hughes, Jeff (2014)
      Objective: There is an increasing incidence of Helicobacter pylori eradication therapy failure secondary to antibiotic resistance. In this study, we aimed to assess the P-glycoprotein expression levels among subjects who ...
    • The influence of passage number for Caco2 cell models when evaluating P-gp mediated drug transport
      Senarathna, Ganga; Crowe, Andrew (2015)
      Caco2 cells are a human adenocarcinoma cell line that forms tight junctions and are widely used to examine bidirectional drug transport as well as P-glycoprotein mediated efflux. Unfortunately Caco2 cell lines can be very ...
    • Interrelationship between Heliobacter pylori and P-glycoprotein: potential role in drug resistance and carcinogenicity
      Omar, Marhanis Salihah (2013)
      The association between P-glycoprotein and Helicobacter pylori infection was explored. We found that P-glycoprotein expression is induced by H. pylori in the upper gastrointestinal tract and influenced by the genetic ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.