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dc.contributor.authorSenarathna, Senarathna Mudiyanselage Dona Kalyani Ganga
dc.contributor.supervisorDr Andrew Crowe
dc.contributor.supervisorProf. Kevin Batty

Allometric scaling was found as a plausible technique for dose determination in children. Permeability and P-glycoprotein efflux transport of antimalarials were determined using in-vitro Caco-2 cells. Mefloquine showed P-glycoprotein inhibition. Amodiaquine, artesunate and artemisone were not P-glycoprotein substrates or inhibitors. Methylene-blue showed some P-glycoprotein mediated efflux. Permeability was high for amodiaquine and artemisone, medium for mefloquine and artesunate and low for methylene-blue. P-glycoprotein was up-regulated when exposed to dihydroartemisinin/artemisone in combinations with amodiaquine/mefloquine.

dc.publisherCurtin University
dc.titlePharmacokinetics and allometric scaling of antimalarial drugs
curtin.departmentSchool od Pharmacy
curtin.accessStatusOpen access

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