Pharmacokinetics and allometric scaling of antimalarial drugs
| dc.contributor.author | Senarathna, Senarathna Mudiyanselage Dona Kalyani Ganga | |
| dc.contributor.supervisor | Dr Andrew Crowe | |
| dc.contributor.supervisor | Prof. Kevin Batty | |
| dc.date.accessioned | 2017-01-30T09:59:28Z | |
| dc.date.available | 2017-01-30T09:59:28Z | |
| dc.date.created | 2015-12-10T06:14:29Z | |
| dc.date.issued | 2015 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/1139 | |
| dc.description.abstract |
Allometric scaling was found as a plausible technique for dose determination in children. Permeability and P-glycoprotein efflux transport of antimalarials were determined using in-vitro Caco-2 cells. Mefloquine showed P-glycoprotein inhibition. Amodiaquine, artesunate and artemisone were not P-glycoprotein substrates or inhibitors. Methylene-blue showed some P-glycoprotein mediated efflux. Permeability was high for amodiaquine and artemisone, medium for mefloquine and artesunate and low for methylene-blue. P-glycoprotein was up-regulated when exposed to dihydroartemisinin/artemisone in combinations with amodiaquine/mefloquine. | |
| dc.language | en | |
| dc.publisher | Curtin University | |
| dc.title | Pharmacokinetics and allometric scaling of antimalarial drugs | |
| dc.type | Thesis | |
| dcterms.educationLevel | PhD | |
| curtin.department | School od Pharmacy | |
| curtin.accessStatus | Open access |