Interrelationship between Heliobacter pylori and P-glycoprotein: potential role in drug resistance and carcinogenicity
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The association between P-glycoprotein and Helicobacter pylori infection was explored. We found that P-glycoprotein expression is induced by H. pylori in the upper gastrointestinal tract and influenced by the genetic polymorphism. Further, reduce P-glycoprotein expression is associated with increased attachment of the bacteria to epithelial cells. Our results support the hypotheses that high levels of P-glycoprotein expression are protective against gastric cancer and may play a role in H.pylori eradication.
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Omar, Marhanis; Crowe, Andrew; Tay, C.; Hughes, Jeff (2014)Objective: There is an increasing incidence of Helicobacter pylori eradication therapy failure secondary to antibiotic resistance. In this study, we aimed to assess the P-glycoprotein expression levels among subjects who ...
P-glycoprotein expression in Helicobacter pylori-positive patients: The influence of MDR1 C3435T polymorphismOmar, Marhanis; Crowe, Andrew; Parsons, Richard; Ee, H.; Tay, C.; Hughes, Jeffery (2012)OBJECTIVE: The aim of this study was to determine whether the presence of Helicobacter pylori (H. pylori) infection and multidrug resistance protein 1 (MDR1) C3435T polymorphism had an influence on P-glycoprotein (P-gp) ...
Senarathna, Ganga; Crowe, Andrew (2015)Caco2 cells are a human adenocarcinoma cell line that forms tight junctions and are widely used to examine bidirectional drug transport as well as P-glycoprotein mediated efflux. Unfortunately Caco2 cell lines can be very ...