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    Biocompatibility of semiconducting AlGaN/GaN material with living cells

    Access Status
    Fulltext not available
    Authors
    Podolska, Anna
    Tham, S.
    Hart, Robert
    Seeber, R.
    Kocan, M.
    Kocan, M.
    Mishra, U.
    Pfleger, K.
    Parish, G.
    Nener, B.
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Podolska, Anna and Tham, Stephanie and Hart, Robert D. and Seeber, Ruth M. and Kocan, Martin and Kocan, Martina and Mishra, Umesh K. and Pfleger, Kevin D.G. and Parish, Gia and Nener, Brett D. 2012. Biocompatibility of semiconducting AlGaN/GaN material with living cells. Sensors and Actuators B: Chemical. 169 (5): pp. 401-406.
    Source Title
    Sensors and Actuators B
    DOI
    10.1016/j.snb.2012.04.015
    ISSN
    09254005
    URI
    http://hdl.handle.net/20.500.11937/12988
    Collection
    • Curtin Research Publications
    Abstract

    With the aim of developing a highly sensitive, mass producible biosensor, we have investigated the growth of human embryonic kidney (HEK) 293 cells on the surface of semiconductor grade AlGaN/GaN heterostructures. Our results demonstrate that, even without specialised surface treatment, a substantial amount of attachment and proliferation of cells is observed. Growth and mortality rates on the AlGaN surface were comparable to standard control culture plates. Quantitative studies of mortality measured by flow cytometry correlate well with qualitative monitoring of biocompatibility. The percentage of dead cells increases marginally with increasing Al concentration. Cell attachment was investigated qualitatively using focused ion beam/scanning electron microscopy (FIB/SEM) and transmission electron microscopy (TEM). Imaging showed strong attachment at the cell/semiconductor interface at the nanometre level. These measurements are the first study of live cell/semiconductor interactions using complementary methods for proliferation, mortality, and attachment, and confirm that the combination of live cells as the biosensing element and AlGaN/GaN heterostructures as the transducer has significant potential for biosensor applications.

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