Optimal 1,3-propanediol production: Exploring the trade-off between process yield and feeding rate variation
dc.contributor.author | Wang, L. | |
dc.contributor.author | Lin, Qun | |
dc.contributor.author | Loxton, Ryan | |
dc.contributor.author | Teo, Kok Lay | |
dc.contributor.author | Cheng, G. | |
dc.date.accessioned | 2017-01-30T11:36:57Z | |
dc.date.available | 2017-01-30T11:36:57Z | |
dc.date.created | 2015-07-14T20:00:44Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Wang, L. and Lin, Q. and Loxton, R. and Teo, K.L. and Cheng, G. 2015. Optimal 1,3-propanediol production: Exploring the trade-off between process yield and feeding rate variation. Journal of Process Control. 32: pp. 1-9. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/13423 | |
dc.identifier.doi | 10.1016/j.jprocont.2015.04.011 | |
dc.description.abstract |
This paper proposes a new optimal control model for the production of 1,3-propanediol (1,3-PD) viamicrobial fed-batch fermentation. The proposed model is governed by a nonlinear multi stage dynamic system with two modes: feeding mode, in which glycerol and alkali substrates are added continuously to the fermentor; and batch mode, in which no substrates are added to the fermentor. The non-standard objective function incorporates both the final 1,3-PD yield and the cost of changing the input feeding rate, which is the control variable for the fed-batch fermentation process. Continuous state inequality constraints are imposed to ensure that the concentrations of biomass, glycerol, and reaction products lie within specified limits. Using the constraint transcription method, we approximate the continuous state inequality constraints by a conventional inequality constraint to yield an approximate parameter optimization problem. We then develop a combined particle swarm and gradient-based optimization algorithm to solve this approximate problem. The paper concludes with simulation results. | |
dc.publisher | Elsevier Ltd. | |
dc.subject | Multistage dynamic systems | |
dc.subject | Fed-batch fermentation | |
dc.subject | Total variationa | |
dc.subject | Nonlinear systems | |
dc.subject | Optimal control | |
dc.title | Optimal 1,3-propanediol production: Exploring the trade-off between process yield and feeding rate variation | |
dc.type | Journal Article | |
dcterms.source.volume | 32 | |
dcterms.source.startPage | 1 | |
dcterms.source.endPage | 9 | |
dcterms.source.issn | 0959-1524 | |
dcterms.source.title | Journal of Process Control | |
curtin.department | Department of Mathematics and Statistics | |
curtin.accessStatus | Open access |