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    Hydrogen sulfide inhibits IL-8 expression in human keratinocytes via MAP kinase signaling

    Access Status
    Open access via publisher
    Authors
    Mirandola, P.
    Gobbi, G.
    Micheloni, C.
    Vaccarezza, Mauro
    Di Marcantonio, D.
    Ruscitti, F.
    De Panfilis, G.
    Vitale, M.
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Mirandola, P. and Gobbi, G. and Micheloni, C. and Vaccarezza, M. and Di Marcantonio, D. and Ruscitti, F. and De Panfilis, G. et al. 2011. Hydrogen sulfide inhibits IL-8 expression in human keratinocytes via MAP kinase signaling. Laboratory Investigation. 91 (8): pp. 1188-1194.
    Source Title
    Laboratory Investigation
    DOI
    10.1038/labinvest.2011.76
    ISSN
    0023-6837
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/14038
    Collection
    • Curtin Research Publications
    Abstract

    Sulfur is able to penetrate the skin, and a sulfur-rich balneotherapy has been suggested to be effective in the treatment of psoriasis. Psoriasis is now considered a genetically programmed, immune-mediated, inflammatory disease, in which intralesional T lymphocytes trigger keratinocytes to proliferate and perpetuate the disease process. Interleukin (IL)-17 and IL-22 produced by Th1/Th17 lymphocytes induce IL-8 secretion by keratinocytes, a key event in the pathogenesis of the disease. It is now clear that mitogen-activated protein kinase (MAPK) (extracellular signal-regulated kinases (ERK) 1 and 2) activity is required for IL-17-induced IL-8 synthesis by keratinocytes, and, in fact, MAPK activity is increased in lesional psoriatic skin. Here, we demonstrate both in vitro and in vivo on primary psoriatic lesions that pharmacological inhibitors of ERKs as well as hydrogen sulfide not only reduce the basal expression and secretion of IL-8, but also interfere with IL-17- and IL-22-induced IL-8 production. These observations, together with the known anti-inflammatory activity of H2S, are relevant to understanding some previously unexplained biological effects exerted by sulfur therapy.

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