Rethinking phosphatidylinositol 3-monophosphate
MetadataShow full item record
A generally accepted view considers phosphatidylinositol 3-monophosphate (PtdIns3P) as a lipid confined to the endosomal compartment where it regulates trafficking pathways and is produced constitutively and exclusively by class III phosphoinositide 3-kinase (PI3K). Recent evidence suggests that this phosphoinositide has a more complex role as a second messenger involved in different physiological and pathological events and that specific intracellular localization of kinases and/or phosphatases is critical for PtdIns3P synthesis and PtdIns3P-dependent intracellular functions. Here, we review the current knowledge of the regulation and function of PtdIns3P and discuss how the view of PtdIns3P changed in the last few years. © 2009 Elsevier B.V. All rights reserved.
Showing items related by title, author, creator and subject.
Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphataseWood, C.; Hung, C.; Huoh, Y.; Mousley, Carl; Stefan, C.; Bankaitis, V.; Ferguson, K.; Burd, C. (2012)In the Golgi apparatus, lipid homeostasis pathways are coordinated with the biogenesis of cargo transport vesicles by phosphatidylinositol 4-kinases (PI4Ks) that produce phosphatidylinositol 4-phosphate (PtdIns4P), a ...
PI3K Class II [alpha] Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium FunctionFranco, I.; Gulluni, F.; Campa, C.; Costa, C.; Margaria, J.; Ciraolo, E.; Martini, M.; Monteyne, D.; De Luca, E.; Germena, G.; Posor, Y.; Maffucci, T.; Marengo, S.; Haucke, V.; Falasca, Marco; Perez-Morga, D.; Boletta, A.; Merlo, G.; Hirsch, E. (2014)Multiple phosphatidylinositol (PtdIns) 3-kinases (PI3Ks) can produce PtdIns3P to control endocytic trafficking, but whether enzyme specialization occurs in defined subcellular locations is unclear. Here, we report that ...
Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolutionSchaaf, G.; Dynowski, M.; Mousley, Carl; Shah, S.; Yuan, P.; Winklbauer, E.; De Campos, M.; Trettin, K.; Quinones, M.; Smirnova, T.; Yanagisawa, L.; Ortlund, E.; Bankaitis, V. (2011)Sec14-superfamily proteins integrate the lipid metabolome with phosphoinositide synthesis and signaling via primed presentation of phosphatidylinositol (PtdIns) to PtdIns kinases. Sec14 action as a PtdIns-presentation ...