Rethinking phosphatidylinositol 3-monophosphate
| dc.contributor.author | Falasca, Marco | |
| dc.contributor.author | Maffucci, T. | |
| dc.date.accessioned | 2017-01-30T11:46:48Z | |
| dc.date.available | 2017-01-30T11:46:48Z | |
| dc.date.created | 2016-09-12T08:36:51Z | |
| dc.date.issued | 2009 | |
| dc.identifier.citation | Falasca, M. and Maffucci, T. 2009. Rethinking phosphatidylinositol 3-monophosphate. Biochimica et Biophysica Acta - Molecular Cell Research. 1793 (12): pp. 1795-1803. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/14939 | |
| dc.identifier.doi | 10.1016/j.bbamcr.2009.10.003 | |
| dc.description.abstract |
A generally accepted view considers phosphatidylinositol 3-monophosphate (PtdIns3P) as a lipid confined to the endosomal compartment where it regulates trafficking pathways and is produced constitutively and exclusively by class III phosphoinositide 3-kinase (PI3K). Recent evidence suggests that this phosphoinositide has a more complex role as a second messenger involved in different physiological and pathological events and that specific intracellular localization of kinases and/or phosphatases is critical for PtdIns3P synthesis and PtdIns3P-dependent intracellular functions. Here, we review the current knowledge of the regulation and function of PtdIns3P and discuss how the view of PtdIns3P changed in the last few years. © 2009 Elsevier B.V. All rights reserved. | |
| dc.title | Rethinking phosphatidylinositol 3-monophosphate | |
| dc.type | Journal Article | |
| dcterms.source.volume | 1793 | |
| dcterms.source.number | 12 | |
| dcterms.source.startPage | 1795 | |
| dcterms.source.endPage | 1803 | |
| dcterms.source.issn | 0167-4889 | |
| dcterms.source.title | Biochimica et Biophysica Acta - Molecular Cell Research | |
| curtin.department | School of Biomedical Sciences | |
| curtin.accessStatus | Open access via publisher |
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