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dc.contributor.authorFalasca, Marco
dc.contributor.authorMaffucci, T.
dc.identifier.citationFalasca, M. and Maffucci, T. 2009. Rethinking phosphatidylinositol 3-monophosphate. Biochimica et Biophysica Acta - Molecular Cell Research. 1793 (12): pp. 1795-1803.

A generally accepted view considers phosphatidylinositol 3-monophosphate (PtdIns3P) as a lipid confined to the endosomal compartment where it regulates trafficking pathways and is produced constitutively and exclusively by class III phosphoinositide 3-kinase (PI3K). Recent evidence suggests that this phosphoinositide has a more complex role as a second messenger involved in different physiological and pathological events and that specific intracellular localization of kinases and/or phosphatases is critical for PtdIns3P synthesis and PtdIns3P-dependent intracellular functions. Here, we review the current knowledge of the regulation and function of PtdIns3P and discuss how the view of PtdIns3P changed in the last few years. © 2009 Elsevier B.V. All rights reserved.

dc.titleRethinking phosphatidylinositol 3-monophosphate
dc.typeJournal Article
dcterms.source.titleBiochimica et Biophysica Acta - Molecular Cell Research
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access via publisher

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