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dc.contributor.authorFalasca, Marco
dc.contributor.authorMaffucci, T.
dc.date.accessioned2017-01-30T11:46:48Z
dc.date.available2017-01-30T11:46:48Z
dc.date.created2016-09-12T08:36:51Z
dc.date.issued2009
dc.date.submitted2016-09-12
dc.identifier.citationFalasca, M. and Maffucci, T. 2009. Rethinking phosphatidylinositol 3-monophosphate. Biochimica et Biophysica Acta - Molecular Cell Research. 1793 (12): pp. 1795-1803.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/14939
dc.identifier.doi10.1016/j.bbamcr.2009.10.003
dc.description.abstract

A generally accepted view considers phosphatidylinositol 3-monophosphate (PtdIns3P) as a lipid confined to the endosomal compartment where it regulates trafficking pathways and is produced constitutively and exclusively by class III phosphoinositide 3-kinase (PI3K). Recent evidence suggests that this phosphoinositide has a more complex role as a second messenger involved in different physiological and pathological events and that specific intracellular localization of kinases and/or phosphatases is critical for PtdIns3P synthesis and PtdIns3P-dependent intracellular functions. Here, we review the current knowledge of the regulation and function of PtdIns3P and discuss how the view of PtdIns3P changed in the last few years. © 2009 Elsevier B.V. All rights reserved.

dc.titleRethinking phosphatidylinositol 3-monophosphate
dc.typeJournal Article
dcterms.dateSubmitted2016-09-12
dcterms.source.volume1793
dcterms.source.number12
dcterms.source.startPage1795
dcterms.source.endPage1803
dcterms.source.issn0167-4889
dcterms.source.titleBiochimica et Biophysica Acta - Molecular Cell Research
curtin.digitool.pid243574
curtin.pubStatusPublished
curtin.refereedTRUE
curtin.departmentSchool of Biomedical Sciences
curtin.identifier.scriptidPUB-VC-ORD-SA-21458
curtin.identifier.elementsidELEMENTS-87261
curtin.accessStatusFulltext not available


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