African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles
MetadataShow full item record
Background: Several studies have demonstrated a lower apolipoprotein E4 (APOE e4) allele frequency in African-Americans, but yet an increased age-related prevalence of AD. An algorithm for prevention clinical trials incorporating TOMM40'523 (Translocase of Outer Mitochondria Membrane) and APOE depends on accurate TOMM40'523-APOE haplotypes. Methods: We have compared the APOE and TOMM40'523 phased haplotype frequencies of a 9.5 kb TOMM40/APOE genomic region in West African, Caucasian, and African-American cohorts. Results: African-American haplotype frequency scans of poly-T lengths connected in phase with either APOE e4 or APOE e3 differ from both West Africans and Caucasians and represent admixture of several distinct West African and Caucasian haplotypes. A new West African TOMM40'523 haplotype, with APOE e4 connected to a short TOMM40'523 allele, is observed in African-Americans but not Caucasians. Conclusion: These data have therapeutic implications for the age of onset risk algorithm estimates and the design of a prevention trial for African-Americans or other mixed ethnic populations.
Showing items related by title, author, creator and subject.
Age at menarche and risk of type 2 diabetes among African-American and white women in the Atherosclerosis Risk in Communities (ARIC) studyDreyfus, J.; Lutsey, P.; Huxley, Rachel; Pankow, J.; Selvin, E.; Fernández-Rhodes, L.; Franceschini, N.; Demerath, E. (2012)Aims/hypothesis: We examined race differences in the association between age at menarche and type 2 diabetes before and after adjustment for adiposity. Methods: We analysed baseline and 9-year follow-up data from 8,491 ...
Can immune-related genotypes illuminate the immunopathogenesis of cytomegalovirus disease in human immunodeficiency virus-infected patients?Affandi, J.; Aghafar, Z.; Rodriguez, B.; Lederman, M.; Burrows, S.; Senitzer, D.; Price, Patricia (2012)Most human immunodeficiency virus (HIV) patients are seropositive for cytomegalovirus (CMV) but a smaller proportion experience end-organ disease. This observation may reflect variations in genes affecting inflammatory ...
Analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: A genetic association studyWadley, A.; Lombard, Z.; Cherry, C.; Price, Patricia; Kamerman, P. (2012)We analyzed GTP cyclohydrolase 1 in symptomatic HIV-associated sensory neuropathy in Southern Africans including a "painprotective" 3-SNP haplotype and 6 SNPs, analyzed individually and in a 6-SNP haplotype. The ...