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dc.contributor.authorRoses, A.
dc.contributor.authorLutz, M.
dc.contributor.authorSaunders, A.
dc.contributor.authorGoldgaber, D.
dc.contributor.authorSaul, R.
dc.contributor.authorSundseth, S.
dc.contributor.authorAkkari, Patrick
dc.contributor.authorRoses, S.
dc.contributor.authorGottschalk, W.
dc.contributor.authorWhitfield, K.
dc.contributor.authorVostrov, A.
dc.contributor.authorHauser, M.
dc.contributor.authorAllingham, R.
dc.contributor.authorBurns, D.
dc.contributor.authorChiba-Falek, O.
dc.contributor.authorWelsh-Bohmer, K.
dc.identifier.citationRoses, A. and Lutz, M. and Saunders, A. and Goldgaber, D. and Saul, R. and Sundseth, S. and Akkari, P. et al. 2014. African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles. Alzheimer's and Dementia. 10 (6): pp. 592-601.

Background: Several studies have demonstrated a lower apolipoprotein E4 (APOE e4) allele frequency in African-Americans, but yet an increased age-related prevalence of AD. An algorithm for prevention clinical trials incorporating TOMM40'523 (Translocase of Outer Mitochondria Membrane) and APOE depends on accurate TOMM40'523-APOE haplotypes. Methods: We have compared the APOE and TOMM40'523 phased haplotype frequencies of a 9.5 kb TOMM40/APOE genomic region in West African, Caucasian, and African-American cohorts. Results: African-American haplotype frequency scans of poly-T lengths connected in phase with either APOE e4 or APOE e3 differ from both West Africans and Caucasians and represent admixture of several distinct West African and Caucasian haplotypes. A new West African TOMM40'523 haplotype, with APOE e4 connected to a short TOMM40'523 allele, is observed in African-Americans but not Caucasians. Conclusion: These data have therapeutic implications for the age of onset risk algorithm estimates and the design of a prevention trial for African-Americans or other mixed ethnic populations.

dc.publisherElsevier Inc.
dc.titleAfrican-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles
dc.typeJournal Article
dcterms.source.titleAlzheimer's and Dementia
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access via publisher

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