Show simple item record

dc.contributor.authorRoses, A.
dc.contributor.authorLutz, M.
dc.contributor.authorSaunders, A.
dc.contributor.authorGoldgaber, D.
dc.contributor.authorSaul, R.
dc.contributor.authorSundseth, S.
dc.contributor.authorAkkari, Patrick
dc.contributor.authorRoses, S.
dc.contributor.authorGottschalk, W.
dc.contributor.authorWhitfield, K.
dc.contributor.authorVostrov, A.
dc.contributor.authorHauser, M.
dc.contributor.authorAllingham, R.
dc.contributor.authorBurns, D.
dc.contributor.authorChiba-Falek, O.
dc.contributor.authorWelsh-Bohmer, K.
dc.date.accessioned2017-01-30T11:50:03Z
dc.date.available2017-01-30T11:50:03Z
dc.date.created2015-10-29T04:10:03Z
dc.date.issued2014
dc.identifier.citationRoses, A. and Lutz, M. and Saunders, A. and Goldgaber, D. and Saul, R. and Sundseth, S. and Akkari, P. et al. 2014. African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles. Alzheimer's and Dementia. 10 (6): pp. 592-601.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/15480
dc.identifier.doi10.1016/j.jalz.2014.06.009
dc.description.abstract

Background: Several studies have demonstrated a lower apolipoprotein E4 (APOE e4) allele frequency in African-Americans, but yet an increased age-related prevalence of AD. An algorithm for prevention clinical trials incorporating TOMM40'523 (Translocase of Outer Mitochondria Membrane) and APOE depends on accurate TOMM40'523-APOE haplotypes. Methods: We have compared the APOE and TOMM40'523 phased haplotype frequencies of a 9.5 kb TOMM40/APOE genomic region in West African, Caucasian, and African-American cohorts. Results: African-American haplotype frequency scans of poly-T lengths connected in phase with either APOE e4 or APOE e3 differ from both West Africans and Caucasians and represent admixture of several distinct West African and Caucasian haplotypes. A new West African TOMM40'523 haplotype, with APOE e4 connected to a short TOMM40'523 allele, is observed in African-Americans but not Caucasians. Conclusion: These data have therapeutic implications for the age of onset risk algorithm estimates and the design of a prevention trial for African-Americans or other mixed ethnic populations.

dc.publisherElsevier Inc.
dc.titleAfrican-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles
dc.typeJournal Article
dcterms.source.volume10
dcterms.source.number6
dcterms.source.startPage592
dcterms.source.endPage601
dcterms.source.issn1552-5260
dcterms.source.titleAlzheimer's and Dementia
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access via publisher


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record