Neuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults
MetadataShow full item record
Background: Albumin serves a range of physiological functions that are vital to overall brain and cognitive health. Indeed, associations between cognitive performance and albumin have been demonstrated in individuals with chronic liver or kidney disease and in patients with a high urinary excretion of albumin. However, an association of plasma albumin with cognitive performance has not been reported in otherwise healthy participants with clinically acceptable plasma albumin concentrations. Method: This study utilized a wide-ranging neuropsychological test battery to investigate the relationship between cognitive performance and plasma albumin homeostasis in 222 healthy participants (143 females) between the ages of 43 and 84 years (mean 65 years). Results: Albumin both with and without the covariates of age, sex and acute-phase proteins was positively associated with enhanced performance on a range of neuropsychological domains including perceptual speed, Stroop and verbal ability. Albumin manifested generally positive but less robust associations with secondary and primary memory. Conclusion: The results indicate that there is a positive association between albumin and cognitive performance in physiologically healthy participants free of chronic renal or liver disease.
Copyright © 2014 S. Karger AG
This is the peer-reviewed but unedited manuscript version of the following article: Neuropsychobiology. 69 (1): pp. 31-38. The final, published version is available at http://www.karger.com/?doi=10.1159/000356967
Showing items related by title, author, creator and subject.
Lack of reliable evidence for a distinctive ε4-related cognitive phenotype that is independent from clinical diagnostic status: findings from the Australian Imaging, Biomarkers and Lifestyle StudyFoster, Jonathan; Albrecht, Matthew; Savage, Greg; Lautenschlager, Nicola T.; Ellis, Kathryn A.; Maruff, Paul; Szoeke, Cassandra; Taddei, Kevin; Martins, Ralph; Masters, Colin L.; Ames, David (2013)Individuals who carry the apolipoprotein E ε4 polymorphism have an increased risk of late-onset Alzheimer’s disease. However, because possession of the ε4 allele confers an increased risk for the diagnosis of dementia, ...
The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older AdultsLam, Virginie; Albrecht, Matthew; Takechi, Ryusuke; Giles, C.; James, Anthony; Foster, Jonathan; Mamo, John (2013)S100B is a calcium binding peptide produced predominantly by astroglial cells in the central nervous system. S100B paradoxically has neurotrophic and apoptotic effects, dependent on extracellular concentration. This study ...
Pushpanathan, M.; Loftus, Andrea; Thomas, M.; Gasson, Natalie; Bucks, R. (2016)© 2015 Elsevier Ltd. It is well established that sleep disorders have neuropsychological consequences in otherwise healthy people. Studies of night-time sleep problems and cognition in Parkinson's disease (PD), however, ...