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    Neuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults

    199616_199616.pdf (324.5Kb)
    Access Status
    Open access
    Authors
    Lam, Virginie
    Albrecht, Matthew
    Takechi, Ryu
    Haidari-Nejad, S.
    Foster, Jonathan
    Mamo, John
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Lam, V. and Albrecht, M. and Takechi, R. and Heidari-Nejad, S. and Foster, J. and Mamo, J. 2014. Neuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults. Neuropsychobiology. 69 (1): pp. 31-38.
    Source Title
    Neuropsychobiology
    DOI
    10.1159/000356967
    ISSN
    1423-0224
    Remarks

    Copyright © 2014 S. Karger AG

    This is the peer-reviewed but unedited manuscript version of the following article: Neuropsychobiology. 69 (1): pp. 31-38. The final, published version is available at http://www.karger.com/?doi=10.1159/000356967

    URI
    http://hdl.handle.net/20.500.11937/19039
    Collection
    • Curtin Research Publications
    Abstract

    Background: Albumin serves a range of physiological functions that are vital to overall brain and cognitive health. Indeed, associations between cognitive performance and albumin have been demonstrated in individuals with chronic liver or kidney disease and in patients with a high urinary excretion of albumin. However, an association of plasma albumin with cognitive performance has not been reported in otherwise healthy participants with clinically acceptable plasma albumin concentrations. Method: This study utilized a wide-ranging neuropsychological test battery to investigate the relationship between cognitive performance and plasma albumin homeostasis in 222 healthy participants (143 females) between the ages of 43 and 84 years (mean 65 years). Results: Albumin both with and without the covariates of age, sex and acute-phase proteins was positively associated with enhanced performance on a range of neuropsychological domains including perceptual speed, Stroop and verbal ability. Albumin manifested generally positive but less robust associations with secondary and primary memory. Conclusion: The results indicate that there is a positive association between albumin and cognitive performance in physiologically healthy participants free of chronic renal or liver disease.

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