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dc.contributor.authorLam, Virginie
dc.contributor.authorAlbrecht, Matthew
dc.contributor.authorTakechi, Ryu
dc.contributor.authorHaidari-Nejad, S.
dc.contributor.authorFoster, Jonathan
dc.contributor.authorMamo, John
dc.date.accessioned2017-01-30T12:11:26Z
dc.date.available2017-01-30T12:11:26Z
dc.date.created2014-07-01T20:00:28Z
dc.date.issued2014
dc.identifier.citationLam, V. and Albrecht, M. and Takechi, R. and Heidari-Nejad, S. and Foster, J. and Mamo, J. 2014. Neuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults. Neuropsychobiology. 69 (1): pp. 31-38.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/19039
dc.identifier.doi10.1159/000356967
dc.description.abstract

Background: Albumin serves a range of physiological functions that are vital to overall brain and cognitive health. Indeed, associations between cognitive performance and albumin have been demonstrated in individuals with chronic liver or kidney disease and in patients with a high urinary excretion of albumin. However, an association of plasma albumin with cognitive performance has not been reported in otherwise healthy participants with clinically acceptable plasma albumin concentrations. Method: This study utilized a wide-ranging neuropsychological test battery to investigate the relationship between cognitive performance and plasma albumin homeostasis in 222 healthy participants (143 females) between the ages of 43 and 84 years (mean 65 years). Results: Albumin both with and without the covariates of age, sex and acute-phase proteins was positively associated with enhanced performance on a range of neuropsychological domains including perceptual speed, Stroop and verbal ability. Albumin manifested generally positive but less robust associations with secondary and primary memory. Conclusion: The results indicate that there is a positive association between albumin and cognitive performance in physiologically healthy participants free of chronic renal or liver disease.

dc.publisherS. Karger AG
dc.subjectPlasma albumin
dc.subjectBayesian analysis
dc.subjectNeurovascular inflammation
dc.subjectNeuropsychological performance
dc.titleNeuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults
dc.typeJournal Article
dcterms.source.volume69
dcterms.source.startPage31
dcterms.source.endPage38
dcterms.source.issn1423-0224
dcterms.source.titleNeuropsychobiology
curtin.note

Copyright © 2014 S. Karger AG

curtin.note

This is the peer-reviewed but unedited manuscript version of the following article: Neuropsychobiology. 69 (1): pp. 31-38. The final, published version is available at http://www.karger.com/?doi=10.1159/000356967

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curtin.accessStatusOpen access


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