View Item 

The Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line

Access Status
Open access
Authors
McLaren, S.
Arfuso, Frank
Zeps, N.
Dharmarajan, Arunasalam
Date
2014
Type
Journal Article

Metadata
Show full item record
Citation
McLaren, S. and Arfuso, F. and Zeps, N. and Dharmarajan, A. 2014. The Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line. Journal of Analytical Oncology. 3: pp. 1-10.
Source Title
Journal of Analytical Oncology
DOI
ISSN
School
School of Biomedical Sciences
Remarks

The link to the journal can be found in the Related links field

URI
Collection
Abstract

The Wnt signalling pathway is involved in regulating cellular proliferation and differentiation, and aberrant activation has been described in several cancers including breast. Oestradiol up regulates Wnt pathway gene expression, and thereby activates the Wnt signalling pathway. We used the oestrogen-responsive breast cancer cell line MCF-7 to examine the effects of secreted frizzled related protein 4 (sFRP-4) on oestradiol-induced growth, including gene expression of the Wnt signalling pathway genes Frizzled Receptor, Wnt-10b, and β-catenin. We demonstrate here that sFRP-4 inhibits oestradiol-induced cell growth in the MCF-7 cell line and also down regulates oestradiol-induced expression of selected Wnt signalling genes including β-catenin. We propose that sFRP-4 is a potent inhibitor of the Wnt signalling pathway and may negatively regulate oestradiol-mediated proliferation in human breast cancer cells.