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dc.contributor.authorMcLaren, S.
dc.contributor.authorArfuso, Frank
dc.contributor.authorZeps, N.
dc.contributor.authorDharmarajan, Arunasalam
dc.date.accessioned2017-01-30T12:17:55Z
dc.date.available2017-01-30T12:17:55Z
dc.date.created2015-02-01T20:00:58Z
dc.date.issued2014
dc.identifier.citationMcLaren, S. and Arfuso, F. and Zeps, N. and Dharmarajan, A. 2014. The Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line. Journal of Analytical Oncology. 3: pp. 1-10.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/20199
dc.identifier.doi10.6000/1927-7229.2014.03.01.1
dc.description.abstract

The Wnt signalling pathway is involved in regulating cellular proliferation and differentiation, and aberrant activation has been described in several cancers including breast. Oestradiol up regulates Wnt pathway gene expression, and thereby activates the Wnt signalling pathway. We used the oestrogen-responsive breast cancer cell line MCF-7 to examine the effects of secreted frizzled related protein 4 (sFRP-4) on oestradiol-induced growth, including gene expression of the Wnt signalling pathway genes Frizzled Receptor, Wnt-10b, and β-catenin. We demonstrate here that sFRP-4 inhibits oestradiol-induced cell growth in the MCF-7 cell line and also down regulates oestradiol-induced expression of selected Wnt signalling genes including β-catenin. We propose that sFRP-4 is a potent inhibitor of the Wnt signalling pathway and may negatively regulate oestradiol-mediated proliferation in human breast cancer cells.

dc.publisherLifescience Global
dc.subjectβ-catenin
dc.subjectcellular proliferation
dc.subjectWnt signalling
dc.subjectoestradiol
dc.subjectsFRP4
dc.subjectBreast cancer
dc.subjectgrowth inhibition
dc.titleThe Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line
dc.typeJournal Article
dcterms.source.volume3
dcterms.source.startPage1
dcterms.source.endPage10
dcterms.source.issn1927-7210
dcterms.source.titleJournal of Analytical Oncology
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curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access


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