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    Proposal for a unified nomenclature for target-site mutations associated with resistance to fungicides

    241499_241499.pdf (10.91Mb)
    Access Status
    Open access
    Authors
    Mair, W.
    Lopez-Ruiz, F.
    Stammler, G.
    Clark, W.
    Burnett, F.
    Hollomon, D.
    Ishii, H.
    Thind, T.
    Brown, J.
    Fraaije, B.
    Cools, H.
    Shaw, M.
    Fillinger, S.
    Walker, A.
    Mellado, E.
    Schnabel, G.
    Mehl, A.
    Oliver, Richard
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Mair, W. and Lopez-Ruiz, F. and Stammler, G. and Clark, W. and Burnett, F. and Hollomon, D. and Ishii, H. et al. 2016. Proposal for a unified nomenclature for target-site mutations associated with resistance to fungicides. Pest Management Science. 72 (8): pp. 1449-1459.
    Source Title
    Pest Management Science
    DOI
    10.1002/ps.4301
    ISSN
    1526-498X
    School
    Centre for Crop Disease Management
    Remarks

    This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

    URI
    http://hdl.handle.net/20.500.11937/20464
    Collection
    • Curtin Research Publications
    Abstract

    Evolved resistance to fungicides is a major problem limiting our ability to control agricultural, medical and veterinary pathogens and is frequently associated with substitutions in the amino acid sequence of the target protein. The convention for describing amino acid substitutions is to cite the wild-type amino acid, the codon number and the new amino acid, using the one-letter amino acid code. It has frequently been observed that orthologous amino acid mutations have been selected in different species by fungicides from the same mode of action class, but the amino acids have different numbers. These differences in numbering arise from the different lengths of the proteins in each species. The purpose of the present paper is to propose a system for unifying the labelling of amino acids in fungicide target proteins. To do this we have produced alignments between fungicide target proteins of relevant species fitted to a well-studied ‘archetype’ species. Orthologous amino acids in all species are then assigned numerical ‘labels’ based on the position of the amino acid in the archetype protein.

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