Associations of objectively assessed Physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: Findings from NHANES (2003-2006)
|dc.identifier.citation||Lynch, B. and Friedenreich, C. and Winkler, E. and Healy, G. and Vallance, J. and Eakin, E. and Owen, N. 2011. Associations of objectively assessed Physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: Findings from NHANES (2003-2006). Breast Cancer Research and Treatment. 130 (1): pp. 183-194.|
Physical activity reduces the risk of postmenopausal breast cancer through multiple inter-related biologic mechanisms; sedentary time may contribute additionally to this risk. We examined cross-sectional associations of objectively assessed physical activity and sedentary time with established biomarkers of breast cancer risk in a population-based sample of postmenopausal women. Accelerometer, anthropometric and laboratory data were available for 1,024 (n = 443 fasting) postmenopausal women in the U.S. National Health and Nutrition Examination Survey 2003-2006. Associations of quartiles of the accelerometer variables (moderate-to vigorousintensity activity, light-intensity activity and sedentary time per day; average length of active and sedentary bouts) with the continuous biomarkers were assessed using linear regression models. Following adjustment for potential confounders, including sedentary time, moderate-to vigorous-intensity activity had significant (P < 0.05), inverse associations with all biomarker outcomes (body mass index, waist circumference, C-reactive protein, fasting plasma glucose, fasting insulin and homeostasis model assessment of insulin resistance). Light-intensity activity and sedentary time were significantly associated in fully adjusted models with all biomarkers except fasting glucose. Active bout length was associated with a smaller waist circumference and lower C-reactive protein levels, while sedentary bout length was associated with a higher BMI. The associations of objectively assessed moderate-to vigorous-intensity activity with breast cancer biomarkers are consistent with the established beneficial effects of selfreported exercise on breast cancer risk. Our findings further suggest that light-intensity activity may have a protective effect, and that sedentary time may independently contribute to breast cancer risk.
|dc.title||Associations of objectively assessed Physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: Findings from NHANES (2003-2006)|
|dcterms.source.title||Breast Cancer Research and Treatment|
|curtin.department||School of Physiotherapy and Exercise Science|
|curtin.accessStatus||Fulltext not available|
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