Sedentary work and the risk of breast cancer in premenopausal and postmenopausal women: A pooled analysis of two case-control studies
MetadataShow full item record
© 2016 by the BMJ Publishing Group Ltd. Objectives: There is limited research on the association between sedentary behaviour and breast cancer risk, particularly whether sedentary behaviour is differentially associated with premenopausal and postmenopausal breast cancer. We pooled data from 2 case-control studies from Australia and Canada to investigate this association. Methods This pooled analysis included 1762 incident breast cancer cases and 2532 controls. Participants in both studies completed a lifetime occupational history and self-rated occupational physical activity level. A jobexposure matrix ( JEM) was also applied to job titles to assess sedentary work. Logistic regression analyses (6 pooled and 12 study-specific) were conducted to estimate associations between both self-reported and JEM-assessed sedentary work and breast cancer risk among premenopausal and postmenopausal women. Results No association was observed in the 6 pooled analyses, and 10 of the study-specific analyses also showed null results. 2 study-specific analyses provided inconsistent and contradictory results, with 1 showing statistically significant increased risk of breast cancer for self-reported sedentary work among premenopausal women cancer in the Canadian study, and the other a non-significant inverse association between JEMassessed sedentary work and breast cancer risk among postmenopausal women in the Australian study. Conclusions While a suggestion of increased risk was seen for premenopausal women in the Canadian study when using the self-reported measure, overall this pooled study does not provide evidence that sedentary work is associated with breast cancer risk.
This article has been accepted for publication in Occupational and Environmental Medicine following peer review. The definitive copyedited, typeset version "Boyle, T. and Fritschi, L. and Kobayashi, L. and Heyworth, J. and Lee, D. and Si, S. and Aronson, K. et al. 2016. Sedentary work and the risk of breast cancer in premenopausal and postmenopausal women: A pooled analysis of two case-control studies. Occupational and Environmental Medicine. 73 (11): pp. 735-741." is available at http://oem.bmj.com/
Showing items related by title, author, creator and subject.
Women commencing anastrozole, letrozole or tamoxifen for early breast cancer: The impact of comorbidity and demographics on initial choiceKemp, A.; Preen, D.; Saunders, C.; Boyle, F.; Bulsara, M.; Holman, C.; Malacova, Eva; Roughead, E. (2014)Background: Australian clinical guidelines recommend endocrine therapy for all women with hormone-dependent early breast cancer. Guidelines specify tamoxifen as first-line therapy for pre-menopausal women, and tamoxifen ...
Si, Si; Boyle, T.; Heyworth, J.; Glass, D.; Saunders, C.; Fritschi, Lin (2015)© 2015 Springer Science+Business Media New York To investigate the association between different types of physical activity (PA) and breast cancer. A case–control study of breast cancer was conducted in Western Australia ...
Neil-Sztramko, S.; Boyle, Terry; Milosevic, E.; Nugent, S.; Gotay, C.; Campbell, K. (2017)Purpose: With only 5–10% of breast cancer cases attributed to genetic inheritance, prevention efforts have focused on modifiable risk factors. Physical activity plays a role in reducing breast cancer risk; however, the ...