Starting blocks-The biochemical basis of contraction-induced signal transduction in skeletal muscle: Starting blocks
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How does skeletal muscle adapt to regular exercise? This question has puzzled and enthused exercise physiologists for the best part of half a century since seminal work by John Holloszy demonstrated the remarkable plasticity of skeletal muscle in response to intense exercise training1. This phenomenon is overtly illustrated by the remodelling of muscle structure and function, with respect to muscular force, endurance and contractile velocity as a result of alterations in functional demand elicited by regular exercise2, or the ability of regular exercise to prevent or ameliorate pathophysiological disease states to which physical inactivity and skeletal muscle insulin resistance contribute3. © Biochemical Society.
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Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in miceMcMahon, C.; Chai, R.; Crabb, Hannah; Watson, T.; Matthews, K.; Sheard, P.; Soffe, Z.; Grounds, M.; Shavlakadze, T. (2014)The age-related loss of skeletal muscle mass and function is termed sarcopenia and has been attributed to a decline in concentrations of insulin-like growth factor-1 (IGF-1). We hypothesized that constitutively expressed ...
Panizzolo, F.; Maiorana, Andrew; Naylor, L.; Dembo, L.; Lloyd, D.; Green, D.; Rubenson, J. (2016)© 2016 Panizzolo et al. Background. Alterations in skeletal muscle function and architecture have been linked to the compromised exercise capacity characterizing chronic heart failure (CHF). However, how passive skeletal ...
Panizzolo, F.; Maiorana, Andrew; Naylor, L.; Lichtwark, G.; Dembo, L.; Lloyd, D.; Green, D.; Rubenson, J. (2015)Purpose: Skeletal muscle wasting is well documented in chronic heart failure (CHF). This article provides a more detailed understanding of the morphology behind this muscle wasting and the relation between muscle morphology, ...