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dc.contributor.authorFiliz, G.
dc.contributor.authorDass, Crispin
dc.date.accessioned2017-01-30T12:26:48Z
dc.date.available2017-01-30T12:26:48Z
dc.date.created2013-03-26T20:00:49Z
dc.date.issued2012
dc.identifier.citationFiliz, G. and Dass, C.R. 2012. Reduction in tumour cell invasion by pigment epithelium-derived factor is mediated by membrane type-1 matrix metalloproteinase downregulation. Die Pharmazie: An International Journal of Pharmaceutical Sciences. 62 (12): pp. 1010-1015.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/21700
dc.identifier.doi10.1691/ph.2012.2067
dc.description.abstract

Prostate cancer and breast cancer are major killers among males and females respectively. In this study, pigment epithelium-derived factor (PEDF) was examined for its effect on commonly used human prostate cancer and human breast cancer cell lines. PEDF increased adhesion of cells to collagen-I, with decreased expression of phosphorylated focal adhesion kinase (p-Fak) consistent between the two cell types. Invasion of both tumour cell types through collagen-I was also reduced by PEDF, with decreased expression of membrane type-1 matrix metalloproteinase (MT1-MMP). These results were confirmed with specific antibodies to MT-MMP1. This study provides some vital clues as to which molecular players are perturbed by PEDF treatment of human prostate and breast cancer cells, raising hope that PEDF can in future be trialled against these major cancers in attempts to procure safer yet effective therapies for cancer.

dc.publisherGovi Verlag Pharmazeutischer Verlag GmbH
dc.titleReduction in tumour cell invasion by pigment epithelium-derived factor is mediated by membrane type-1 matrix metalloproteinase downregulation
dc.typeJournal Article
dcterms.source.volume62
dcterms.source.number12
dcterms.source.startPage1010
dcterms.source.endPage1015
dcterms.source.issn0031-7144
dcterms.source.titleDie Pharmazie
curtin.department
curtin.accessStatusFulltext not available


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