Bioreactor design for tendon/ligament engineering
MetadataShow full item record
Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, design preferences, and criteria that are required for the development of an ideal bioreactor for engineering tendons and ligaments.
Showing items related by title, author, creator and subject.
Wang, Tao; Lin, Zhen; Day, Robert; Gardiner, Bruce; Landao-Bassonga, Euphemie; Rubenson, Jonas; Kirk, Brett; Smith, David; Lloyd, David; Hardisty, Gerard; Wang, Allan; Zheng, Qiujian; Zheng, Ming Hao (2013)Identification of functional programmable mechanical stimulation (PMS) on tendon not only provides the insight of the tendon homeostasis under physical/pathological condition, but also guides a better engineering strategy ...
High-resolution study of the 3D collagen fibrillary matrix of Achilles tendons without tissue labelling and dehydratingWu, Jian-Ping; Swift, B.; Becker, Thomas; Squelch, Andrew; Wang, A.; Zheng, Y.; Zhao, X.; Xu, J.; Xue, W.; Zheng, M.; Lloyd, D.; Kirk, Brett (2017)Â© 2017 The Authors Journal of Microscopy Â© 2017 Royal Microscopical Society Knowledge of the collagen structure of an Achilles tendon is critical to comprehend the physiology, biomechanics, homeostasis and remodelling ...
Wang, T.; Lin, Z.; Ni, M.; Thien, C.; Day, R.; Gardiner, B.; Rubenson, J.; Kirk, Brett; Smith, D.; Wang, A.; Lloyd, D.; Wang, Y.; Zheng, Q.; Zheng, M. (2015)Physiotherapy is one of the effective treatments for tendinopathy, whereby symptoms are relieved by changing the biomechanical environment of the pathological tendon. However, the underlying mechanism remains unclear. In ...