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dc.contributor.authorWang, T.
dc.contributor.authorGardiner, B.
dc.contributor.authorLin, Z.
dc.contributor.authorRubenson, J.
dc.contributor.authorKirk, Thomas
dc.contributor.authorWang, A.
dc.contributor.authorXu, J.
dc.contributor.authorSmith, D.
dc.contributor.authorLloyd, D.
dc.contributor.authorZheng, M.
dc.date.accessioned2017-01-30T12:38:07Z
dc.date.available2017-01-30T12:38:07Z
dc.date.created2013-03-17T20:00:36Z
dc.date.issued2012
dc.identifier.citationTao Wang, B.S. and Gardiner, Bruce S. and Lin, Zhen and Rubenson, Jonas and Kirk, Thomas B. and Wang, Allan and Xu, Jiake and Smith, David W. and Lloyd, David G. and Zheng, Ming H. 2012. Bioreactor design for tendon/ligament engineering. Tissue Engineering Part B: Reviews. 19 (2): pp. 133-146.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/23593
dc.identifier.doi10.1089/ten.teb.2012.0295
dc.description.abstract

Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, design preferences, and criteria that are required for the development of an ideal bioreactor for engineering tendons and ligaments.

dc.publisherMary Ann Liebert Inc Publishers
dc.subjecttendons
dc.subjectbioreactor
dc.subjectligaments
dc.titleBioreactor design for tendon/ligament engineering
dc.typeJournal Article
dcterms.source.volume19
dcterms.source.number2
dcterms.source.startPage133
dcterms.source.endPage146
dcterms.source.issn1937-3368
dcterms.source.titleTissue Engineering Part B: Reviews
curtin.department
curtin.accessStatusFulltext not available


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