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dc.contributor.authorCruzat, Vinicius
dc.contributor.authorRogero, M.
dc.contributor.authorTirapegui, J.
dc.date.accessioned2017-01-30T12:38:49Z
dc.date.available2017-01-30T12:38:49Z
dc.date.created2016-09-12T08:36:51Z
dc.date.issued2010
dc.identifier.citationCruzat, V. and Rogero, M. and Tirapegui, J. 2010. Effects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise. Cell Biochemistry and Function. 28 (1): pp. 24-30.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/23729
dc.identifier.doi10.1002/cbf.1611
dc.description.abstract

In this study, we investigated the effect of the supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine on plasma levels markers of muscle damage and levels of pro-inflammatory cytokines and glutamine metabolism in rats submitted to prolonged exercise. Rats were submitted to sessions of swim training for 6 weeks. Twenty-one days prior to euthanasia, the animals were supplemented with DIP (n=8) (1.5 g.kg-1), a solution of free L-glutamine (1 g.kg -1) and free L-alanine (0.61 g.kg-1) (G&A, n=8) or water (control (CON), n=8). Animals were killed at rest before (R), after prolonged exercise (PE - 2 h of exercise). Plasma concentrations of glutamine, glutamate, tumour necrosis factor-a (TNF-a), prostaglandin E2 (PGE2) and activity of creatine kinase (CK), lactate dehydrogenase (LDH) and muscle concentrations of glutamine and glutamate were measured. The concentrations of plasma TNF-a, PGE2 and the activity of CK were lower in the G&A-R and DIP-R groups, compared to the CON-R. Glutamine in plasma ( p<0.04) and soleus muscle (p<0.001) was higher in the DIP-R and G&A-R groups relative to the CON-R group. G&A-PE and DIP-PE groups exhibited lower concentrations of plasma PGE2 ( p<0.05) and TNF-a (p<0.05), and higher concentrations of glutamine and glutamate in soleus (p<0.001) and gastrocnemius muscles ( p<0.05) relative to the CON-PE group. We concluded that supplementation with free L-glutamine and the dipeptide LL-alanyl-LL-glutamine represents an effective source of glutamine, which may attenuate inflammation biomarkers after periods of training and plasma levels of CK and the inflammatory response induced by prolonged exercise. Copyright © 2009 John Wiley & Sons, Ltd.

dc.titleEffects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise
dc.typeJournal Article
dcterms.source.volume28
dcterms.source.number1
dcterms.source.startPage24
dcterms.source.endPage30
dcterms.source.issn0263-6484
dcterms.source.titleCell Biochemistry and Function
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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