Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent
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Authors
Liu, Lihong
Huang, Y.
Riduan, S.
Gao, S.
Yang, Y.
Fan, W.
Zhang, Y.
Date
2012Type
Journal Article
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Liu, L. and Huang, Y. and Riduan, S. and Gao, S. and Yang, Y. and Fan, W. and Zhang, Y. 2012. Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent. Biomaterials. 33 (33): pp. 8625-8631.
Source Title
Biomaterials
ISSN
School
Department of Chemical Engineering
Collection
Abstract
Human health has been challenged by multi-drug-resistant microorganisms for several decades. Herein, we have developed a main-chain imidazolium oligomer (IBN-1) material to combat broad spectrum of pathogenic strains, including drug-resistant Klebsiella pneumoniae, Vancomycin-resistant enterococcus, Methicillin-resistant Staphylococcus aureus and fluconazole-resistant yeast Cryptococcus neoformans, while displaying minimal hemolysis (HC50/MIC values over 3000) and a very high therapeutic index of 37 for killing S. aureus under inflammatory conditions in vivo.
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