Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent
| dc.contributor.author | Liu, Lihong | |
| dc.contributor.author | Huang, Y. | |
| dc.contributor.author | Riduan, S. | |
| dc.contributor.author | Gao, S. | |
| dc.contributor.author | Yang, Y. | |
| dc.contributor.author | Fan, W. | |
| dc.contributor.author | Zhang, Y. | |
| dc.date.accessioned | 2017-01-30T12:42:06Z | |
| dc.date.available | 2017-01-30T12:42:06Z | |
| dc.date.created | 2015-10-29T04:09:23Z | |
| dc.date.issued | 2012 | |
| dc.identifier.citation | Liu, L. and Huang, Y. and Riduan, S. and Gao, S. and Yang, Y. and Fan, W. and Zhang, Y. 2012. Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent. Biomaterials. 33 (33): pp. 8625-8631. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/24294 | |
| dc.identifier.doi | 10.1016/j.biomaterials.2012.08.006 | |
| dc.description.abstract |
Human health has been challenged by multi-drug-resistant microorganisms for several decades. Herein, we have developed a main-chain imidazolium oligomer (IBN-1) material to combat broad spectrum of pathogenic strains, including drug-resistant Klebsiella pneumoniae, Vancomycin-resistant enterococcus, Methicillin-resistant Staphylococcus aureus and fluconazole-resistant yeast Cryptococcus neoformans, while displaying minimal hemolysis (HC50/MIC values over 3000) and a very high therapeutic index of 37 for killing S. aureus under inflammatory conditions in vivo. | |
| dc.title | Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent | |
| dc.type | Journal Article | |
| dcterms.source.volume | 33 | |
| dcterms.source.number | 33 | |
| dcterms.source.startPage | 8625 | |
| dcterms.source.endPage | 8631 | |
| dcterms.source.issn | 0142-9612 | |
| dcterms.source.title | Biomaterials | |
| curtin.department | Department of Chemical Engineering | |
| curtin.accessStatus | Fulltext not available |
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