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dc.contributor.authorAl-Salami, Hani
dc.contributor.authorButt, G.
dc.contributor.authorTucker, I.
dc.contributor.authorFawcett, P.
dc.contributor.authorGolocorbin-Kon, S.
dc.contributor.authorMikov, I.
dc.contributor.authorMikov, M.
dc.date.accessioned2017-01-30T12:48:38Z
dc.date.available2017-01-30T12:48:38Z
dc.date.created2013-03-21T20:00:58Z
dc.date.issued2009
dc.identifier.citationAl-Salami, Hani and Butt, Grant and Tucker, Ian and Fawcett, Paul J. and Golocorbin-Kon, Svetlana and Mikov, Ivan and Mikov, Momir. 2009. Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats. European Journal of Drug Metabolism and Pharmacokinetics. 34 (1): pp. 43-50.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/25466
dc.description.abstract

The aim is to investigate the influence of the antidiabetic drug gliclazide on the ileal permeation of the semisynthetic bile acid, MKC, in tissues from healthy and diabetic rats. Sixteen Wistar rats (350 +/- 50 g) were randomly allocated into four groups (4 rats per group, 8 chambers per rat, i.e., n=32) two of which were made diabetic (given alloxan i.v. 30 mg/kg). Group 1 was used to measure the permeation of MKC (50 microg/ml) alone (control) while group 2 to measure MKC permeation in the presence of gliclazide (200 microg/ml). The diabetic groups 3 (gliclazide) and 4 (MKC+gliclazide) were treated in the same way. Rats were sacrificed and tissues were mounted into the Ussing chamber for the measurement of MKC mucosal to serosal (absorptive) and serosal to mucosal (secretory) fluxes. In healthy tissues, gliclazide reduced MKC absorptive flux (p < 0.01) and increased its secretory flux (p < 0.01). In diabetic tissues, gliclazide had no effect on either the absorptive or the secretory fluxes of MKC. The lack of effect of gliclazide on MKC permeation in diabetic tissues suggests the absence or suppressed drug transporters. Furthermore, gliclazide inhibition of MKC absorptive flux and induction of MKC secretory flux in healthy tissues may result from the selective inhibition of an efflux drug transporter.

dc.publisherSpringer France
dc.subjectpermeation
dc.subjectMrp3
dc.subjecttransporters
dc.subjectgliclazide
dc.subjectdiabetes
dc.subjectbile acid
dc.titleGliclazide reduces MKC intestinal transport in healthy but not diabetic rats
dc.typeJournal Article
dcterms.source.volume34
dcterms.source.number1
dcterms.source.startPage43
dcterms.source.endPage50
dcterms.source.issn0378-7966
dcterms.source.titleEuropean Journal of Drug Metabolism and Pharmacokinetics
curtin.department
curtin.accessStatusFulltext not available


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