Interrelationship between Heliobacter pylori and P-glycoprotein: potential role in drug resistance and carcinogenicity
| dc.contributor.author | Omar, Marhanis Salihah | |
| dc.contributor.supervisor | Prof. Jeffery Hughes | |
| dc.contributor.supervisor | Dr Andrew Crowe | |
| dc.date.accessioned | 2017-01-30T10:23:35Z | |
| dc.date.available | 2017-01-30T10:23:35Z | |
| dc.date.created | 2013-11-26T07:02:41Z | |
| dc.date.issued | 2013 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/2586 | |
| dc.description.abstract |
The association between P-glycoprotein and Helicobacter pylori infection was explored. We found that P-glycoprotein expression is induced by H. pylori in the upper gastrointestinal tract and influenced by the genetic polymorphism. Further, reduce P-glycoprotein expression is associated with increased attachment of the bacteria to epithelial cells. Our results support the hypotheses that high levels of P-glycoprotein expression are protective against gastric cancer and may play a role in H.pylori eradication. | |
| dc.language | en | |
| dc.publisher | Curtin University | |
| dc.title | Interrelationship between Heliobacter pylori and P-glycoprotein: potential role in drug resistance and carcinogenicity | |
| dc.type | Thesis | |
| dcterms.educationLevel | PhD | |
| curtin.department | School of Pharmacy | |
| curtin.accessStatus | Open access |