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    Comparative studies of the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine against bovine mastitis using non-invasive mouse mastitis as a model system

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    Authors
    Gogoi Tiwari, Jully
    Williams, Vincent
    Waryah, C.
    Eto, K.
    Tau, M.
    Costantino, Paul
    Tiwari, H.
    Mukkur, Trilochan
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Gogoi Tiwari, J. and Williams, V. and Waryah, C. and Eto, K. and Tau, M. and Costantino, P. and Tiwari, H. et al. 2015. Comparative studies of the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine against bovine mastitis using non-invasive mouse mastitis as a model system. Biofouling. 31 (7): pp. 543-554.
    Source Title
    Biofouling
    DOI
    10.1080/08927014.2015.1074681
    ISSN
    0892-7014
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/27859
    Collection
    • Curtin Research Publications
    Abstract

    This study was undertaken to compare the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine for the prevention of mastitis using the mouse as a model system. Mice immunized with formalin-killed whole cell vaccine of S. aureus residing in a biofilm when delivered via an intramammary route produced a cell mediated immune response. Mice immunized with this biofilm vaccine showed significant reductions in colonization by S. aureus in mammary glands, severity of clinical symptoms and tissue damage in mammary glands in comparison with the mice immunized with formalin-killed whole cells of planktonic S. aureus. The planktonic vaccine administered by a subcutaneous route produced a significantly higher humoral immune response (IgG1 and IgG) than the biofilm vaccine. However, considering the host response, tissue damage, the clinical severity and colonization of S. aureus in mammary glands, the biofilm vaccine performed better in immunogenicity and protective potential when administered by the intramammary route.

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