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    Biofilm forming potential and antimicrobial susceptibility of newly emerged Western Australian Bordetella pertussis clinical isolates

    Access Status
    Fulltext not available
    Authors
    Dorji, D.
    Graham, Ross
    Richmond, P.
    Keil, A.
    Mukkur, T.
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Dorji, D. and Graham, R. and Richmond, P. and Keil, A. and Mukkur, T. 2016. Biofilm forming potential and antimicrobial susceptibility of newly emerged Western Australian Bordetella pertussis clinical isolates. Biofouling. 32 (9): pp. 1141-1152.
    Source Title
    Biofouling
    DOI
    10.1080/08927014.2016.1232715
    ISSN
    0892-7014
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/29145
    Collection
    • Curtin Research Publications
    Abstract

    Whooping cough caused by Bordetella pertussis is increasing in several countries despite high vaccine coverage. One potential reason for the resurgence is the emergence of genetic variants of the bacterium. Biofilm formation has recently been associated with the pathogenesis of B. pertussis. Biofilm formation of 21 Western Australian B. pertussis clinical isolates was investigated. All isolates formed thicker biofilms than the reference vaccine strain Tohama I while retaining susceptibility to ampicillin, erythromycin, azithromycin and streptomycin. When two biofilm-forming clinical isolates were compared with Tohama I, minimum bactericidal concentrations of antimicrobial agents increased. Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis revealed significant differences in protein expression in B. pertussis biofilms, providing an opportunity for identification of novel biofilm-associated antigens for incorporation in current pertussis vaccines to improve their protective efficacy. The study also highlights the importance of determining antibiograms for biofilms to formulate improved antimicrobial therapeutic regimens.

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