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dc.contributor.authorCalton, E.
dc.contributor.authorKeane, Kevin
dc.contributor.authorSoares, Mario
dc.identifier.citationCalton, E. and Keane, K. and Soares, M. 2015. The potential regulatory role of Vitamin D in the bioenergetics of inflammation. Current Opinion in Clinical Nutrition and Metabolic Care. 18 (4): pp. 367-373.

Purpose of review The extraskeletal health benefits of vitamin D still need scientific endorsement. Obesity and related chronic diseases are pathogenically linked by inflammation, which carries a considerable energetic cost. Recent techniques for the determination of the bioenergetic demand of inflammation, offer an avenue to cement the regulatory role of vitamin D in this process. Recent findings Nuclear vitamin D receptors may be translocated into mitochondria of certain cell types, opening up a pathway for direct action on cellular bioenergetics. Classical M1 (inflammatory)/M2(anti-inflammatory) phenotypes can vary with the clinical context. M2 macrophages do not always depend on oxidative metabolism/fatty acid oxidation. Newer methodologies offer real-time bioenergetic measurements that can be used as an index of metabolic health. Summary Vitamin D may prove to be a therapeutic agent for inflammation of chronic disease and understanding its role in cellular bioenergetics may offer a diagnostic/prognostic indicator of its action.

dc.publisherLippincott Williams and Wilkins
dc.titleThe potential regulatory role of Vitamin D in the bioenergetics of inflammation
dc.typeJournal Article
dcterms.source.titleCurrent Opinion in Clinical Nutrition and Metabolic Care
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available

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