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A Clonal Complex 12 Methicillin-Resistant Staphylococcus aureus Strain, West Australian MRSA-59, Harbors a Novel Pseudo-SCCmec Element

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Authors
Monecke, S.
Coombs, Geoffrey
Pearson, J.
Hotzel, H.
Slickers, P.
Ehricht, R.
Date
2015
Type
Journal Article

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Monecke, S. and Coombs, G. and Pearson, J. and Hotzel, H. and Slickers, P. and Ehricht, R. 2015. A Clonal Complex 12 Methicillin-Resistant Staphylococcus aureus Strain, West Australian MRSA-59, Harbors a Novel Pseudo-SCCmec Element. Antimicrobial Agents and Chemotherapy. 59 (11): pp. 7142-7144.
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Antimicrobial Agents and Chemotherapy
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School of Biomedical Sciences
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Abstract

Copyright © 2015, American Society for Microbiology. All Rights Reserved. A West Australian methicillin-resistant Staphylococcus aureus strain (WA MRSA-59) was characterized by microarray and sequencing. Its pseudo-staphylococcal cassette chromosome mec (SCCmec) element comprised dcs, Q9XB68-dcs, mvaS-SCC, Q5HJW6, dru, ugpQ, ydeM, mecA-mecR-mecI, txbi mecI, tnp IS431, copA2-mco (copper resistance), ydhK, arsC-arsB-arsR (arsenic resistance), open reading frame PT43, and per-2. Recombinase genes, xylR (mecR2), and PSM-mec (phenol-soluble modulin) were absent. We suggest that mec complex A should be split into two subtypes. One harbors PSM-mec and xylR (mecR2). It is found in SCCmec types II, III, and VIII. The second subtype, described herein, is present in WA MRSA-59 and some coagulasenegative staphylococci.