Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level

    226444.pdf (1.602Mb)
    Access Status
    Open access
    Authors
    Shtukenberg, A.
    Poloni, L.
    Zhu, Z.
    An, Z.
    Bhandari, M.
    Song, P.
    Rohl, Andrew
    Kahr, B.
    Ward, M.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Shtukenberg, A. and Poloni, L. and Zhu, Z. and An, Z. and Bhandari, M. and Song, P. and Rohl, A. et al. 2015. Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level. Crystal Growth & Design. 15: pp. 921-934.
    Source Title
    Crystal Growth & Design
    DOI
    10.1021/cg501485e
    ISSN
    1528-7483
    School
    Nanochemistry Research Institute
    Funding and Sponsorship
    http://purl.org/au-research/grants/arc/DP140101776
    Remarks

    This research was supported by the Australian Research Council (Grant number DP140101776)

    URI
    http://hdl.handle.net/20.500.11937/33037
    Collection
    • Curtin Research Publications
    Abstract

    Crystallization of L-cystine is a critical process in the pathogenesis of kidney stone formation in cystinuria, a disorder affecting more than 20 000 individuals in the United States alone. In an effort to elucidate the crystallization of L-cystine and the mode of action of tailored growth inhibitors that may constitute effective therapies, real-time in situ atomic force microscopy has been used to investigate the surface micromorphology and growth kinetics of the {0001} faces of L-cystine at various supersaturations and concentrations of the growth inhibitor L-cystine dimethylester (CDME). Crystal growth is actuated by screw dislocations on the {0001} L-cystine surface, producing hexagonal spiral hillocks that are a consequence of six interlacing spirals of anisotropic molecular layers. The high level of elastic stress in the immediate vicinity around the dislocation line results in a decrease in the step velocities and a corresponding increase in the spacing of steps. The kinetic curves acquired in the presence of CDME conform to the classical Cabrera–Vermilyea model. Anomalous birefringence in the {101̅0} growth sectors, combined with computational modeling, supports a high fidelity of stereospecific binding of CDME, in a unique orientation, exclusively at one of the six crystallographically unique projections on the {1010} plane.

    Related items

    Showing items related by title, author, creator and subject.

    • Predicting crystal growth via a unified kinetic three-dimensional partition model
      Anderson, M.; Gebbie-Rayet, J.; Hill, A.; Farida, N.; Attfield, M.; Cubillas, P.; Blatov, V.; Proserpio, D.; Akporiaye, D.; Arstad, B.; Gale, Julian (2017)
      Understanding and predicting crystal growth is fundamental to the control of functionality in modern materials. Despite investigations for more than one hundred years, it is only recently that the molecular intricacies ...
    • Selenium incorporation into calcite and its effect on crystal growth: An atomic force microscopy study
      Renard, F.; Montes-Hernandez, G.; Ruiz-Agudo, E.; Putnis, Christine (2013)
      The atomic processes leading to calcite growth are still debated. The presence of foreign impurities in solution is known to change the rate of step propagation during growth as well as the growth mechanism. Among trace ...
    • Solubility and crystal growth of sodium nitrate from mixed alcohol – water solvents
      Rossiter, Angelina Jane (2009)
      Due to the ductile nature of the sodium nitrate crystal which deforms plastically under high levels of strain, most of the crystal growth studies in aqueous solution have focussed on the influence of tensile strain, ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.