Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level
dc.contributor.author | Shtukenberg, A. | |
dc.contributor.author | Poloni, L. | |
dc.contributor.author | Zhu, Z. | |
dc.contributor.author | An, Z. | |
dc.contributor.author | Bhandari, M. | |
dc.contributor.author | Song, P. | |
dc.contributor.author | Rohl, Andrew | |
dc.contributor.author | Kahr, B. | |
dc.contributor.author | Ward, M. | |
dc.date.accessioned | 2017-01-30T13:34:33Z | |
dc.date.available | 2017-01-30T13:34:33Z | |
dc.date.created | 2015-05-22T08:32:16Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Shtukenberg, A. and Poloni, L. and Zhu, Z. and An, Z. and Bhandari, M. and Song, P. and Rohl, A. et al. 2015. Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level. Crystal Growth & Design. 15: pp. 921-934. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/33037 | |
dc.identifier.doi | 10.1021/cg501485e | |
dc.description.abstract |
Crystallization of L-cystine is a critical process in the pathogenesis of kidney stone formation in cystinuria, a disorder affecting more than 20 000 individuals in the United States alone. In an effort to elucidate the crystallization of L-cystine and the mode of action of tailored growth inhibitors that may constitute effective therapies, real-time in situ atomic force microscopy has been used to investigate the surface micromorphology and growth kinetics of the {0001} faces of L-cystine at various supersaturations and concentrations of the growth inhibitor L-cystine dimethylester (CDME). Crystal growth is actuated by screw dislocations on the {0001} L-cystine surface, producing hexagonal spiral hillocks that are a consequence of six interlacing spirals of anisotropic molecular layers. The high level of elastic stress in the immediate vicinity around the dislocation line results in a decrease in the step velocities and a corresponding increase in the spacing of steps. The kinetic curves acquired in the presence of CDME conform to the classical Cabrera–Vermilyea model. Anomalous birefringence in the {101̅0} growth sectors, combined with computational modeling, supports a high fidelity of stereospecific binding of CDME, in a unique orientation, exclusively at one of the six crystallographically unique projections on the {1010} plane. | |
dc.publisher | American Chemical Society | |
dc.relation.sponsoredby | http://purl.org/au-research/grants/arc/DP140101776 | |
dc.subject | kidney stone formation - atomic force microscope - crystallization kinetics | |
dc.title | Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level | |
dc.type | Journal Article | |
dcterms.source.volume | 15 | |
dcterms.source.startPage | 921 | |
dcterms.source.endPage | 934 | |
dcterms.source.issn | 1528-7483 | |
dcterms.source.title | Crystal Growth & Design | |
curtin.note |
This research was supported by the Australian Research Council (Grant number DP140101776) | |
curtin.department | Nanochemistry Research Institute | |
curtin.accessStatus | Open access |