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dc.contributor.authorShtukenberg, A.
dc.contributor.authorPoloni, L.
dc.contributor.authorZhu, Z.
dc.contributor.authorAn, Z.
dc.contributor.authorBhandari, M.
dc.contributor.authorSong, P.
dc.contributor.authorRohl, Andrew
dc.contributor.authorKahr, B.
dc.contributor.authorWard, M.
dc.identifier.citationShtukenberg, A. and Poloni, L. and Zhu, Z. and An, Z. and Bhandari, M. and Song, P. and Rohl, A. et al. 2015. Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level. Crystal Growth & Design. 15: pp. 921-934.

Crystallization of L-cystine is a critical process in the pathogenesis of kidney stone formation in cystinuria, a disorder affecting more than 20 000 individuals in the United States alone. In an effort to elucidate the crystallization of L-cystine and the mode of action of tailored growth inhibitors that may constitute effective therapies, real-time in situ atomic force microscopy has been used to investigate the surface micromorphology and growth kinetics of the {0001} faces of L-cystine at various supersaturations and concentrations of the growth inhibitor L-cystine dimethylester (CDME). Crystal growth is actuated by screw dislocations on the {0001} L-cystine surface, producing hexagonal spiral hillocks that are a consequence of six interlacing spirals of anisotropic molecular layers. The high level of elastic stress in the immediate vicinity around the dislocation line results in a decrease in the step velocities and a corresponding increase in the spacing of steps. The kinetic curves acquired in the presence of CDME conform to the classical Cabrera–Vermilyea model. Anomalous birefringence in the {101̅0} growth sectors, combined with computational modeling, supports a high fidelity of stereospecific binding of CDME, in a unique orientation, exclusively at one of the six crystallographically unique projections on the {1010} plane.

dc.publisherAmerican Chemical Society
dc.subjectkidney stone formation - atomic force microscope - crystallization kinetics
dc.titleDislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level
dc.typeJournal Article
dcterms.source.titleCrystal Growth & Design

This research was supported by the Australian Research Council (Grant number DP140101776)

curtin.departmentNanochemistry Research Institute
curtin.accessStatusOpen access

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