Surprising performance of alginate beads for the release of low-molecular-weight drugs
MetadataShow full item record
The model of low-molecular-weight drugs has been encapsulated within alginate beads hardened with calcium chloride. The drug's release kinetic using 3% (w/v) alginate has shown a surprising behavior after 2 h, where the release kinetic was shifted from Fickian to case II transport mechanism contradicting other authors like Akihiko et al. (J Control Release 1999, 58, 21). To support this finding, we studied the swelling of dried gel beads of 2 and 3% (w/v) alginate, which showed a sudden decrease in the swelling of 3% (w/v) alginate after 2 h due to a partial bursting of the beads. This sudden bursting was clearly observed using the optical microscope to emphasize the new findings. Calcium alginate beads revealed pH sensitivity, where 2% (w/v) alginate beads showed a maximum swelling of 5000% in alkaline medium at pH 7.4, compared with a negligible swelling percent of 60% in acidic medium (pH 1.2). Accordingly, it could be a good candidate for targeting smart and low-molecular-weight drugs to the intestine. © 2010 Wiley Periodicals, Inc.
Showing items related by title, author, creator and subject.
Release and swelling studies of an innovative antidiabetic-bile acid microencapsulated formulation, as a novel targeted therapy for diabetes treatmentMooranian, Armin; Negrulj, Rebecca; Al-Sallami, H.; Fang, Zhongxiang; Mikov, M.; Golocorbin-Kon, S.; Fakhoury, M.; Arfuso, Frank; Al-Salami, Hani (2015)In previous studies carried out in our laboratory, a bile acid formulation exerted a hypoglycaemic effect in a rat model of type 1 diabetes (T1D). When the antidiabetic drug gliclazide was added to the bile acid, it ...
Probucol Release from Novel Multicompartmental Microcapsules for the Oral Targeted Delivery in Type 2 DiabetesMooranian, Armin; Negrulj, Rebecca; Al-Sallami, H.; Fang, Zhongxiang; Mikov, Momir; Golocorbin-Kon, S.; Fakhoury, M.; Watts, G.; Matthews, V.; Arfuso, Frank; Lambros, Amanda; Al-Salami, Hani (2014)In previous studies, we developed and characterised multicompartmental microcapsules as a platform for the targeted oral delivery of lipophilic drugs in type 2 diabetes (T2D). We also designed a new microencapsulated ...
The effect of a tertiary bile acid, taurocholic acid, on the morphology and physical characteristics of microencapsulated probucol: potential applications in diabetes: a characterization studyMooranian, A.; Negrulj, R.; Arfuso, Frank; Al-Salami, Hani (2015)In recent studies, we designed multi-compartmental microcapsules as a platform for the targeted oral delivery of lipophilic drugs in an animal model of type 2 diabetes (T2D). Probucol (PB) is a highly lipophilic, ...