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dc.contributor.authorElnashar, Magdy
dc.contributor.authorYassin, M.
dc.contributor.authorEl-Fetouh Abdel Moneim, A.
dc.contributor.authorBary, E.
dc.date.accessioned2017-01-30T13:41:11Z
dc.date.available2017-01-30T13:41:11Z
dc.date.created2016-09-12T08:36:58Z
dc.date.issued2010
dc.identifier.citationElnashar, M. and Yassin, M. and El-Fetouh Abdel Moneim, A. and Bary, E. 2010. Surprising performance of alginate beads for the release of low-molecular-weight drugs. Journal of Applied Polymer Science. 116 (5): pp. 3021-3026.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/34087
dc.identifier.doi10.1002/app.31836
dc.description.abstract

The model of low-molecular-weight drugs has been encapsulated within alginate beads hardened with calcium chloride. The drug's release kinetic using 3% (w/v) alginate has shown a surprising behavior after 2 h, where the release kinetic was shifted from Fickian to case II transport mechanism contradicting other authors like Akihiko et al. (J Control Release 1999, 58, 21). To support this finding, we studied the swelling of dried gel beads of 2 and 3% (w/v) alginate, which showed a sudden decrease in the swelling of 3% (w/v) alginate after 2 h due to a partial bursting of the beads. This sudden bursting was clearly observed using the optical microscope to emphasize the new findings. Calcium alginate beads revealed pH sensitivity, where 2% (w/v) alginate beads showed a maximum swelling of 5000% in alkaline medium at pH 7.4, compared with a negligible swelling percent of 60% in acidic medium (pH 1.2). Accordingly, it could be a good candidate for targeting smart and low-molecular-weight drugs to the intestine. © 2010 Wiley Periodicals, Inc.

dc.publisherJohn Wiley and Sons Inc
dc.titleSurprising performance of alginate beads for the release of low-molecular-weight drugs
dc.typeJournal Article
dcterms.source.volume116
dcterms.source.number5
dcterms.source.startPage3021
dcterms.source.endPage3026
dcterms.source.issn0021-8995
dcterms.source.titleJournal of Applied Polymer Science
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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