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dc.contributor.authorCasadio, Y.
dc.contributor.authorBrown, David
dc.contributor.authorChirila, T.
dc.contributor.authorKraatz, H.
dc.contributor.authorBaker, M.
dc.date.accessioned2017-01-30T13:46:07Z
dc.date.available2017-01-30T13:46:07Z
dc.date.created2010-11-28T20:02:55Z
dc.date.issued2010
dc.identifier.citationCasadio, Ylenia S. and Brown, David H. and Chirila, Traian V. and Kraatz, Heinz-Bernhard and Baker, Murray V. 2010. Biodegradation of Poly(2-hydroxyethyl methacrylate) (PHEMA) and Poly{(2-hydroxyethyl methacrylate)-co-[poly(ethylene glycol) methyl ether methacrylate]} Hydrogels Containing Peptide-Based Cross-Linking Agents. Biomacromolecules. 11: pp. 2949-2959.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/34842
dc.identifier.doi10.1021/bm100756c
dc.description.abstract

PHEMA-peptide and P[HEMA-co-(MeO-PEGMA)]-peptide conjugate hydrogels [where PHEMA ) poly(2-hydroxyethyl methacrylate; PEGMA ) poly(ethylene glycol) methacrylate] were readily prepared via photoinitiated free-radical polymerization in water. The PHEMA-peptide hydrogels were opaque and had a heterogeneous morphology of interconnected polymer droplets, characteristic of polymers that separate from the aqueous phase during the polymerization experiment. The P[HEMA-co-(MeO-PEGMA)]-peptide conjugates were transparent gels with a homogeneous morphology when formed in water, but when formed in aqueous NaCl solutions the P[HEMA-co-(MeO-PEGMA)]-peptide conjugates were also opaque and exhibited the heterogeneous morphology of interconnected polymer droplets. When incubated in solutions containing activated papain, P[HEMA-co-(MeOPEGMA)]- peptide conjugates underwent degradation that was characterized by macroscopic changes to sample shape and size, sample weight, and microscopic structure. PHEMA-peptide conjugates did not undergo any significant degradation when incubated with papain, although ninhydrin-staining experiments suggested that some peptide cross-linker groups were cleaved during the incubation. The difference in degradation behavior of PHEMA-peptide and P[HEMA-co-(MeO-PEGMA)]-peptide conjugates is attributed to differences in aqueous solubility of PHEMA and P[HEMA-co-(MeO-PEGMA)].

dc.publisherAmerican Chemical Society
dc.titleBiodegradation of Poly(2-hydroxyethyl methacrylate) (PHEMA) and Poly{(2-hydroxyethyl methacrylate)-co-[poly(ethylene glycol) methyl ether methacrylate]} Hydrogels ContainingPeptide-Based Cross-Linking Agents
dc.typeJournal Article
dcterms.source.volume11
dcterms.source.startPage2949
dcterms.source.endPage2959
dcterms.source.issn15257797
dcterms.source.titleBiomacromolecules
curtin.departmentNanochemistry Research Institute (Research Institute)
curtin.accessStatusFulltext not available
curtin.facultyNanochemistry Research Institute (NRI)
curtin.facultyFaculty of Science and Engineering


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