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    Childhood Brain Tumours: Associations With Parental Occupational Exposure to Solvents

    202722_134613_Childhood_Brain_Tumors.pdf (128.1Kb)
    Access Status
    Open access
    Authors
    Peters, S.
    Glass, D.
    Greenop, K.
    Armstrong, B.
    Kirby, M.
    Milne, Elizabeth
    Fritschi, Lin
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Peters, S. and Glass, D. and Greenop, K. and Armstrong, B. and Kirby, M. and Milne, E. and Fritschi, L. 2014. Childhood Brain Tumours: Associations With Parental Occupational Exposure to Solvents. British Journal of Cancer. 111 (5): pp. 998-1003.
    Source Title
    British Journal of Cancer
    DOI
    10.1038/bjc.2014.358
    ISSN
    0007-0920
    School
    School of Public Health
    Remarks

    This open access article is distributed under the Creative Commons license https://creativecommons.org/licenses/by-nc-sa/3.0/au/

    URI
    http://hdl.handle.net/20.500.11937/34999
    Collection
    • Curtin Research Publications
    Abstract

    Background: Parental occupational exposures have been associated with childhood brain tumours (CBT), but results are inconsistent. Few studies have studied CBT risk and parental solvent exposure, suggesting a possible association. We examined the association between CBT and parental occupational exposure to solvents in a case–control study.Methods: Parents of 306 cases and 950 controls completed detailed occupational histories. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for both maternal and paternal exposure to benzene, other aromatics, aliphatics and chlorinated solvents in key time periods relative to the birth of their child. Adjustments were made for matching variables (child’s age, sex and state of residence), best parental education and occupational exposure to diesel exhaust.Results: An increased risk of CBT was observed with maternal occupational exposures to chlorinated solvents (OR=8.59, 95% CI 0.94–78.9) any time before birth. Paternal exposure to solvents in the year before conception was associated with an increased CBT risk: OR=1.55 (95% CI 0.99–2.43). This increased risk appeared to be mainly attributable to exposure to aromatic solvents: OR=2.72 (95% CI 0.94–7.86) for benzene and OR=1.76 (95% CI 1.10–2.82) for other aromatics.Conclusions: Our results indicate that parental occupational exposures to solvents may be related to an increased risk of CBT.

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