Childhood Brain Tumours: Associations With Parental Occupational Exposure to Solvents
MetadataShow full item record
Background: Parental occupational exposures have been associated with childhood brain tumours (CBT), but results are inconsistent. Few studies have studied CBT risk and parental solvent exposure, suggesting a possible association. We examined the association between CBT and parental occupational exposure to solvents in a case–control study.Methods: Parents of 306 cases and 950 controls completed detailed occupational histories. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for both maternal and paternal exposure to benzene, other aromatics, aliphatics and chlorinated solvents in key time periods relative to the birth of their child. Adjustments were made for matching variables (child’s age, sex and state of residence), best parental education and occupational exposure to diesel exhaust.Results: An increased risk of CBT was observed with maternal occupational exposures to chlorinated solvents (OR=8.59, 95% CI 0.94–78.9) any time before birth. Paternal exposure to solvents in the year before conception was associated with an increased CBT risk: OR=1.55 (95% CI 0.99–2.43). This increased risk appeared to be mainly attributable to exposure to aromatic solvents: OR=2.72 (95% CI 0.94–7.86) for benzene and OR=1.76 (95% CI 1.10–2.82) for other aromatics.Conclusions: Our results indicate that parental occupational exposures to solvents may be related to an increased risk of CBT.
This open access article is distributed under the Creative Commons license https://creativecommons.org/licenses/by-nc-sa/3.0/au/
Showing items related by title, author, creator and subject.
Glass, D.; Heyworth, J.; Thomson, Allyson; Peters, S.; Saunders, C.; Fritschi, Lin (2015)Background: Occupational exposure to some organic solvents may increase risk of breast cancer. Methods: In a population-based case-control study, 1,205 women diagnosed with primary breast cancer between 2009 and 2011 were ...
Musculoskeletal outcomes in children using computers : a model representing the relationships between user correlates, computer exposure and musculoskeletal outcomesHarris, Courtenay (2010)The etiology of musculoskeletal outcomes associated with the use of information technology (IT) has predominately been defined by studies of adults in their work environments. Theories explaining the causation of work ...
Risk of childhood acute lymphoblastic leukaemia following parental occupational exposure to pesticidesGlass, D.; Reid, A.; Bailey, H.; Milne, E.; Fritschi, Lin (2012)Objective: To ascertain whether there was an association between parental occupational exposure to pesticides and increased risk of acute lymphoblastic leukaemia (ALL) in the offspring. Method: A population-based case–control ...