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dc.contributor.authorPeters, S.
dc.contributor.authorGlass, D.
dc.contributor.authorGreenop, K.
dc.contributor.authorArmstrong, B.
dc.contributor.authorKirby, M.
dc.contributor.authorMilne, Elizabeth
dc.contributor.authorFritschi, Lin
dc.date.accessioned2017-01-30T13:46:59Z
dc.date.available2017-01-30T13:46:59Z
dc.date.created2014-10-14T20:00:17Z
dc.date.issued2014
dc.identifier.citationPeters, S. and Glass, D. and Greenop, K. and Armstrong, B. and Kirby, M. and Milne, E. and Fritschi, L. 2014. Childhood Brain Tumours: Associations With Parental Occupational Exposure to Solvents. British Journal of Cancer. 111 (5): pp. 998-1003.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/34999
dc.identifier.doi10.1038/bjc.2014.358
dc.description.abstract

Background: Parental occupational exposures have been associated with childhood brain tumours (CBT), but results are inconsistent. Few studies have studied CBT risk and parental solvent exposure, suggesting a possible association. We examined the association between CBT and parental occupational exposure to solvents in a case–control study.Methods: Parents of 306 cases and 950 controls completed detailed occupational histories. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for both maternal and paternal exposure to benzene, other aromatics, aliphatics and chlorinated solvents in key time periods relative to the birth of their child. Adjustments were made for matching variables (child’s age, sex and state of residence), best parental education and occupational exposure to diesel exhaust.Results: An increased risk of CBT was observed with maternal occupational exposures to chlorinated solvents (OR=8.59, 95% CI 0.94–78.9) any time before birth. Paternal exposure to solvents in the year before conception was associated with an increased CBT risk: OR=1.55 (95% CI 0.99–2.43). This increased risk appeared to be mainly attributable to exposure to aromatic solvents: OR=2.72 (95% CI 0.94–7.86) for benzene and OR=1.76 (95% CI 1.10–2.82) for other aromatics.Conclusions: Our results indicate that parental occupational exposures to solvents may be related to an increased risk of CBT.

dc.publisherNature Publishing Group
dc.subjectaromatic solvents
dc.subjectchildhood cancer
dc.subjectaliphatic solvents
dc.subjectbenzene
dc.subjectchlorinated solvents
dc.titleChildhood Brain Tumours: Associations With Parental Occupational Exposure to Solvents
dc.typeJournal Article
dcterms.source.volume111
dcterms.source.startPage998
dcterms.source.endPage1003
dcterms.source.issn0007-0920
dcterms.source.titleBritish Journal of Cancer
curtin.note

This open access article is distributed under the Creative Commons license https://creativecommons.org/licenses/by-nc-sa/3.0/au/

curtin.departmentSchool of Public Health
curtin.accessStatusOpen access


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