Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Hypoxia prolongs monocyte/macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions

    Access Status
    Open access via publisher
    Authors
    Roiniotis, J.
    Dinh, H.
    Masendycz, P.
    Turner, A.
    Elsegood, Caryn
    Scholz, G.
    Hamilton, J.
    Date
    2009
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Roiniotis, J. and Dinh, H. and Masendycz, P. and Turner, A. and Elsegood, C. and Scholz, G. and Hamilton, J. 2009. Hypoxia prolongs monocyte/macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions. Journal of Immunology. 182 (12): pp. 7974-7981.
    Source Title
    Journal of Immunology
    DOI
    10.4049/jimmunol.0804216
    ISSN
    0022-1767
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/37597
    Collection
    • Curtin Research Publications
    Abstract

    In chronic inflammatory lesions macrophages are abundant and adapt to the low oxygen concentrations often present there. In low oxygen some cell types die by apoptosis, as reported for macrophage cell lines, while others survive better as they shift their metabolism to anaerobic glycolysis. It was found here that hypoxia prolongs the survival of murine bone marrow-derived macrophages, either in the absence or presence of low CSF-1 (M-CSF) concentrations. Although Akt activity increased in bone marrow-derived macrophages in the low oxygen conditions, the levels of both anti- and proapoptotic Bcl-2 family members decreased. Glycolysis was enhanced as judged by increased glucose uptake, glucose transporter expression, lactate dehydrogenase mRNA expression, and lactate secretion. Human monocytes responded similarly to low oxygen, and a number of genes associated with glycolysis were shown by microarray analysis and quantitative PCR to be up-regulated. Interestingly, human monocytederived macrophages showed evidence of enhanced glycolysis even under aerobic conditions. It is proposed that certain monocyte/macrophage populations survive better under conditions of low oxygen, thereby contributing to their increased numbers at sites of chronic inflammation and tumors; it is also proposed that as macrophages differentiate from monocytes they begin to adopt a glycolytic metabolism allowing them to adapt readily when exposed to low oxygen conditions. Copyright © 2009 by The American Association of Immunologists, Inc.

    Related items

    Showing items related by title, author, creator and subject.

    • A past and present overview of macrophage metabolism and functional outcomes
      Curi, R.; Mendes, R.; Crispin, L.; Norata, G.; Sampaio, S.; Newsholme, Philip (2017)
      © 2017 The Author(s). In 1986 and 1987, Philip Newsholme et al. reported macrophages utilize glutamine, as well as glucose, at high rates. These authors measured key enzyme activities and consumption and production levels ...
    • Phosphatidylinostitol-3 kinase and phospholipase C enhance CSF-1-dependent macrophage survival by controlling glucose uptake
      Chang, M.; Hamilton, J.; Scholz, G.; Masendycz, P.; Macaulay, S.; Elsegood, Caryn (2009)
      Colony stimulating factor-1 (CSF-1)-dependent macrophages play crucial roles in the development and progression of several pathological conditions including atherosclerosis and breast cancer metastasis. Macrophages in ...
    • Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration
      Elsegood, Caryn; Chan, C.; Degli-Esposti, M.; Wikstrom, M.; Domenichini, A.; Lazarus, K.; van Rooijen, N.; Ganss, R.; Olynyk, John; Yeoh, G. (2015)
      Liver progenitor cells (LPCs) are necessary for repair in chronic liver disease because the remaining hepatocytes cannot replicate. However, LPC numbers also correlate with disease severity and hepatocellular carcinoma ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.