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    Efficient drug delivery using SiO2-layered double hydroxide nanocomposites

    Access Status
    Fulltext not available
    Authors
    Li, L.
    Gu, Z.
    Gu, W.
    Liu, Jian
    Xu, Z.
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Li, L. and Gu, Z. and Gu, W. and Liu, J. and Xu, Z. 2016. Efficient drug delivery using SiO2-layered double hydroxide nanocomposites. Journal of Colloid and Interface Science. 470: pp. 47-55.
    Source Title
    Journal of Colloid and Interface Science
    DOI
    10.1016/j.jcis.2016.02.042
    ISSN
    0021-9797
    School
    Department of Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/40818
    Collection
    • Curtin Research Publications
    Abstract

    MgAl-layered double hydroxide (MgAl-LDH) nanoparticles have great potentials in drug and siRNA delivery. In this work, we used a nanodot-coating strategy to prepare SiO2 dot-coated layered double hydroxide (SiO2@MgAl-LDH) nanocomposites with good dispersibility and controllable size for drug delivery. The optimal SiO2@MgAl-LDH nanocomposite was obtained by adjusting synthetic parameters including the mass ratio of MgAl-LDH to SiO2, the mixing temperature and time. The optimal SiO2@MgAl-LDH nanocomposite was shown to have SiO2 nanodots (10–15 nm in diameter) evenly deposited on the surface of MgAl-LDHs (110 nm in diameter) with the plate-like morphology and the average hydrodynamic diameter of 170 nm. We further employed SiO2@MgAl-LDH nanocomposite as a nanocarrier to deliver methotrexate (MTX), a chemotherapy drug, to the human osteosarcoma cell (U2OS) and found that MTX delivered by SiO2@MgAl-LDH nanocomposite apparently inhibited the U2OS cell growth.

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