Efficient drug delivery using SiO2-layered double hydroxide nanocomposites
dc.contributor.author | Li, L. | |
dc.contributor.author | Gu, Z. | |
dc.contributor.author | Gu, W. | |
dc.contributor.author | Liu, Jian | |
dc.contributor.author | Xu, Z. | |
dc.date.accessioned | 2017-01-30T14:45:53Z | |
dc.date.available | 2017-01-30T14:45:53Z | |
dc.date.created | 2016-04-17T19:30:35Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Li, L. and Gu, Z. and Gu, W. and Liu, J. and Xu, Z. 2016. Efficient drug delivery using SiO2-layered double hydroxide nanocomposites. Journal of Colloid and Interface Science. 470: pp. 47-55. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/40818 | |
dc.identifier.doi | 10.1016/j.jcis.2016.02.042 | |
dc.description.abstract |
MgAl-layered double hydroxide (MgAl-LDH) nanoparticles have great potentials in drug and siRNA delivery. In this work, we used a nanodot-coating strategy to prepare SiO2 dot-coated layered double hydroxide (SiO2@MgAl-LDH) nanocomposites with good dispersibility and controllable size for drug delivery. The optimal SiO2@MgAl-LDH nanocomposite was obtained by adjusting synthetic parameters including the mass ratio of MgAl-LDH to SiO2, the mixing temperature and time. The optimal SiO2@MgAl-LDH nanocomposite was shown to have SiO2 nanodots (10–15 nm in diameter) evenly deposited on the surface of MgAl-LDHs (110 nm in diameter) with the plate-like morphology and the average hydrodynamic diameter of 170 nm. We further employed SiO2@MgAl-LDH nanocomposite as a nanocarrier to deliver methotrexate (MTX), a chemotherapy drug, to the human osteosarcoma cell (U2OS) and found that MTX delivered by SiO2@MgAl-LDH nanocomposite apparently inhibited the U2OS cell growth. | |
dc.publisher | Academic Press | |
dc.title | Efficient drug delivery using SiO2-layered double hydroxide nanocomposites | |
dc.type | Journal Article | |
dcterms.source.volume | 470 | |
dcterms.source.startPage | 47 | |
dcterms.source.endPage | 55 | |
dcterms.source.issn | 0021-9797 | |
dcterms.source.title | Journal of Colloid and Interface Science | |
curtin.department | Department of Chemical Engineering | |
curtin.accessStatus | Fulltext not available |
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