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dc.contributor.authorLi, L.
dc.contributor.authorGu, Z.
dc.contributor.authorGu, W.
dc.contributor.authorLiu, Jian
dc.contributor.authorXu, Z.
dc.identifier.citationLi, L. and Gu, Z. and Gu, W. and Liu, J. and Xu, Z. 2016. Efficient drug delivery using SiO2-layered double hydroxide nanocomposites. Journal of Colloid and Interface Science. 470: pp. 47-55.

MgAl-layered double hydroxide (MgAl-LDH) nanoparticles have great potentials in drug and siRNA delivery. In this work, we used a nanodot-coating strategy to prepare SiO2 dot-coated layered double hydroxide (SiO2@MgAl-LDH) nanocomposites with good dispersibility and controllable size for drug delivery. The optimal SiO2@MgAl-LDH nanocomposite was obtained by adjusting synthetic parameters including the mass ratio of MgAl-LDH to SiO2, the mixing temperature and time. The optimal SiO2@MgAl-LDH nanocomposite was shown to have SiO2 nanodots (10–15 nm in diameter) evenly deposited on the surface of MgAl-LDHs (110 nm in diameter) with the plate-like morphology and the average hydrodynamic diameter of 170 nm. We further employed SiO2@MgAl-LDH nanocomposite as a nanocarrier to deliver methotrexate (MTX), a chemotherapy drug, to the human osteosarcoma cell (U2OS) and found that MTX delivered by SiO2@MgAl-LDH nanocomposite apparently inhibited the U2OS cell growth.

dc.publisherAcademic Press
dc.titleEfficient drug delivery using SiO2-layered double hydroxide nanocomposites
dc.typeJournal Article
dcterms.source.titleJournal of Colloid and Interface Science
curtin.departmentDepartment of Chemical Engineering
curtin.accessStatusFulltext not available

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