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    The impact of allylamine-bile acid combinations on cell delivery microcapsules in diabetes

    Access Status
    Fulltext not available
    Authors
    Mooranian, Armin
    Negrulj, Rebecca
    Al-Salami, Hani
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Mooranian, A. and Negrulj, R. and Al-Salami, H. 2016. The impact of allylamine-bile acid combinations on cell delivery microcapsules in diabetes. Journal of Microencapsulation. 33 (6): pp. 569-574.
    Source Title
    Journal of Microencapsulation
    DOI
    10.1080/02652048.2016.1228703
    ISSN
    0265-2048
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/43230
    Collection
    • Curtin Research Publications
    Abstract

    © 2016 Informa UK Limited, trading as Taylor & Francis Group. Objective: In a recent study, we developed a new microencapsulating method for ß-cell microencapsulation, but cell viability declined rapidly, post microencapsulation, due to potential polymer-polyelectrolyte chelation and non-porous microcapsules’ membranes resulting in cell apoptosis. Thus, this study tested the effects of incorporating cationic polyamine at 1% w/v, on microcapsule strength and cell viability, in the absence or presence of an anionic tertiary bile acid (ATBA) with potential cell-protective effects. Methods: 1% w/v polyamine was used without or with ATBA, to form ß-cell microcapsules and physical and biological analyses was carried out 50?h post microencapsulation. Results: Microcapsules containing 1% w/v polyamine showed weak physical properties and low cell viability and ATBA incorporation resulted in >30% reduction in cell viability and increased levels of pro-inflammatory cytokines. Conclusion: Neither 1% w/v polyamine nor the presence of ATBA resulted in optimised cell viability, but rather reduced cell viability, enhanced inflammation and lowered insulin secretion.

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