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dc.contributor.authorLim, Wei Ling
dc.contributor.authorLam, Sin Man
dc.contributor.authorShui, Guanghou
dc.contributor.authorMondal, Alinda
dc.contributor.authorOng, Daniel
dc.contributor.authorDuan, Xinrui
dc.contributor.authorCreegan, Rhona
dc.contributor.authormartins, Ian
dc.contributor.authorSharman, Matthew
dc.contributor.authorTaddei, Kevin
dc.contributor.authorVerdile, Giuseppe
dc.contributor.authorWenk, Markus
dc.contributor.authorMartins, Ralph
dc.identifier.citationLim, Wei Ling Florence and Lam, Sin Man and Shui, Guanghou and Mondal, Alinda and Ong, Daniel and Duan, Xinrui and Creegan, Rhona et al. 2013. Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice. Neurobiology of Aging. 34: pp. 2217-2224.

Apolipoprotein E (ApoE) is important in facilitating the transport of lipids (cholesterol, phospholipids, and sulfatides) and plays a fundamental role in normal lipid metabolism. High cholesterol levels increases the risk of developing Alzheimer’s disease. In this study, we investigated the effects of a high-fat high cholesterol (HFHC) diet on brain lipid profiles in 95 young and aged APOE ε3 and ε4 knock-in mice to determine whether diet leads to altered brain levels of a number of glycerophospholipids, sphingolipids, cholesterol precursors, cholesterol, cholesterol oxidation products, and cholesterol esters. The results in this study revealed significant changes in lipid levels. The HFHC-enriched diet influenced the levels of cholesterol esters. A sharp increase in cholesterol ester levels, particularly in the aged APOE ε4 diet-enriched group, might be suggestive of abnormal acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT) activity and/or levels. Age exerts appreciable effects on the brain lipidome, especially with regard to polar lipid species.

dc.publisherElsevier Inc.
dc.subjectHigh cholesterol
dc.subjectMass spectrometry
dc.subjectHigh fat
dc.subjectAPOE KI mice
dc.titleEffects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice
dc.typeJournal Article
dcterms.source.titleNeurobiology of Aging
curtin.accessStatusFulltext not available

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