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dc.contributor.authorLiew, Emily
dc.contributor.authorNandong, Jobrun
dc.contributor.authorSamyudia, Yudi
dc.contributor.editorKariwala, Vinay; Samavedham, Lakshminarayanan; Braatz, Richard D.
dc.date.accessioned2017-01-30T15:15:33Z
dc.date.available2017-01-30T15:15:33Z
dc.date.created2013-01-10T20:00:33Z
dc.date.issued2012
dc.identifier.citationLiew, E.W.T. and Nandong, J. and Samyudia, Y. 2012. Multi-scale models for the optimization of batch bioreactors, in Proceedings of the 8th IFAC International Symposium on Advanced Control of Chemical Processes (ADCHEM), Jul 10-13 2012. Singapore: International Federation of Automatic Control.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/44640
dc.description.abstract

In this paper, we propose multi-scale models for a batch bioreactor, which are developed by expanding the so-called Herbert’s Microbial Kinetics (HMK) concept so that the effects of mixing conditions are incorporated via the inclusion of the aeration rate and stirrer speed into the microbial kinetics. By using the multi-scale models, we are able to optimize the batch bioreactor’s performances, i.e. yield and productivity, by adjusting the aeration rate and stirrer speed. Simulation and experimental studies on a batch (fermentation) bioreactor demonstrate the application of this approach, whereby the integration of the expanded HMK model with the Computational Fluid Dynamics (CFD) model of mixing, which we call it as a Kinetics Multi-Scale (KMS) model, is able to predict the experimental values of yield and productivity of the batch fermentation process accurately (with less than 5% errors).

dc.publisherIFAC
dc.titleMulti-scale models for the optimization of batch bioreactors
dc.typeConference Paper
dcterms.source.startPage834
dcterms.source.endPage839
dcterms.source.titleThe proceedings of IFAC International Symposium on Advanced Control of Chemical Processes 2012
dcterms.source.seriesThe proceedings of IFAC International Symposium on Advanced Control of Chemical Processes 2012
dcterms.source.isbn978-3-902823-05-2
dcterms.source.conferenceIFAC International Symposium on Advanced Control of Chemical Processes 2012
dcterms.source.conference-start-dateJul 10 2012
dcterms.source.conferencelocationSingapore
dcterms.source.placeUK
curtin.department
curtin.accessStatusOpen access


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