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    A one-pot, three-component, microwave-assisted synthesis of novel 7-amino-substituted 4-aminopyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles

    Access Status
    Fulltext not available
    Authors
    Lim, F.
    Luna, Giuseppe
    Dolzhenko, Anton
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Lim, F. and Luna, G. and Dolzhenko, A. 2015. A one-pot, three-component, microwave-assisted synthesis of novel 7-amino-substituted 4-aminopyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles. Tetrahedron Letters. 56: pp. 7016-7019.
    Source Title
    Tetrahedron Letters
    DOI
    10.1016/j.tetlet.2015.11.006
    ISSN
    0040-4039
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/44655
    Collection
    • Curtin Research Publications
    Abstract

    The synthesis of novel 7-amino-substituted pyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles was achieved via a three-component reaction of 3-amino-substituted 5-aminopyrazole-4-carbonitriles, cyanamide and triethyl orthoformate under microwave irradiation. Under catalyst-free conditions, this three-component reaction accommodated a generous diversity of amino substituents making it ideal for the generation of compound libraries for drug discovery processes.

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