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    Transit Time Affects the Community Stability of Lactobacillus and Bifidobacterium Species in an In Vitro Model of Human Colonic Microbiotia

    Access Status
    Fulltext not available
    Authors
    Rodes, L.
    Paul, A.
    Coussa-Charley, M.
    Al-Salami, Hani
    Tomaro-Duchesneau, C.
    Fakhoury, M.
    Prakash, S.
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Rodes, Laetitia and Paul, Arghya and Coussa-Charley, Michael and Al-Salami, Hani and Tomaro-Duchesneau, Catherine and Fakhoury, Marc and Prakash, Satya. 2011. Transit Time Affects the Community Stability of Lactobacillus and Bifidobacterium Species in an In Vitro Model of Human Colonic Microbiotia. Artificial Cells, Blood Substitutes and Biotechnology. 39 (6): pp. 351-356.
    Source Title
    Artificial Cells, Blood Substitutes and Biotechnology
    DOI
    10.3109/10731199.2011.622280
    ISSN
    1073-1199
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/47605
    Collection
    • Curtin Research Publications
    Abstract

    Retention time, which is analogous to transit time, is an index for bacterial stability in the intestine. Its consideration is of particular importance to optimize the delivery of probiotic bacteria in order to improve treatment efficacy. This study aims to investigate the effect of retention time on Lactobacilli and Bifidobacteria stability using an established in vitro human colon model. Three retention times were used: 72, 96, and 144 h. The effect of retention time on cell viability of different bacterial populations was analyzed with bacterial plate counts and PCR. The proportions of intestinal Bifidobacteria, Lactobacilli, Enterococci, Staphylococci and Clostridia populations, analyzed by plate counts, were found to be the same as that in human colonic microbiota. Retention time in the human colon affected the stability of Lactobacilli and Bifidobacteria communities, with maximum stability observed at 144 h. Therefore, retention time is an important parameter that influences bacterial stability in the colonic microbiota. Future clinical studies on probiotic bacteria formulations should take into consideration gastrointestinal transit parameters to improve treatment efficacy.

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