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dc.contributor.authorRodes, L.
dc.contributor.authorPaul, A.
dc.contributor.authorCoussa-Charley, M.
dc.contributor.authorAl-Salami, Hani
dc.contributor.authorTomaro-Duchesneau, C.
dc.contributor.authorFakhoury, M.
dc.contributor.authorPrakash, S.
dc.date.accessioned2017-01-30T15:34:24Z
dc.date.available2017-01-30T15:34:24Z
dc.date.created2012-02-05T20:00:35Z
dc.date.issued2011
dc.identifier.citationRodes, Laetitia and Paul, Arghya and Coussa-Charley, Michael and Al-Salami, Hani and Tomaro-Duchesneau, Catherine and Fakhoury, Marc and Prakash, Satya. 2011. Transit Time Affects the Community Stability of Lactobacillus and Bifidobacterium Species in an In Vitro Model of Human Colonic Microbiotia. Artificial Cells, Blood Substitutes and Biotechnology. 39 (6): pp. 351-356.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/47605
dc.identifier.doi10.3109/10731199.2011.622280
dc.description.abstract

Retention time, which is analogous to transit time, is an index for bacterial stability in the intestine. Its consideration is of particular importance to optimize the delivery of probiotic bacteria in order to improve treatment efficacy. This study aims to investigate the effect of retention time on Lactobacilli and Bifidobacteria stability using an established in vitro human colon model. Three retention times were used: 72, 96, and 144 h. The effect of retention time on cell viability of different bacterial populations was analyzed with bacterial plate counts and PCR. The proportions of intestinal Bifidobacteria, Lactobacilli, Enterococci, Staphylococci and Clostridia populations, analyzed by plate counts, were found to be the same as that in human colonic microbiota. Retention time in the human colon affected the stability of Lactobacilli and Bifidobacteria communities, with maximum stability observed at 144 h. Therefore, retention time is an important parameter that influences bacterial stability in the colonic microbiota. Future clinical studies on probiotic bacteria formulations should take into consideration gastrointestinal transit parameters to improve treatment efficacy.

dc.publisherInforma Healthcare
dc.titleTransit Time Affects the Community Stability of Lactobacillus and Bifidobacterium Species in an In Vitro Model of Human Colonic Microbiotia
dc.typeJournal Article
dcterms.source.volume39
dcterms.source.number6
dcterms.source.startPage351
dcterms.source.endPage356
dcterms.source.issn1073-1199
dcterms.source.titleArtificial Cells, Blood Substitutes and Biotechnology
curtin.departmentSchool of Pharmacy
curtin.accessStatusFulltext not available


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