The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88
dc.contributor.author | Puneet, P. | |
dc.contributor.author | McGrath, M. | |
dc.contributor.author | Tay, H. | |
dc.contributor.author | Al-Riyami, L. | |
dc.contributor.author | Rzepecka, J. | |
dc.contributor.author | Moochhala, S. | |
dc.contributor.author | Pervaiz, Shazib | |
dc.contributor.author | Harnett, M. | |
dc.contributor.author | Harnett, W. | |
dc.contributor.author | Melendez, A. | |
dc.date.accessioned | 2017-03-17T08:30:05Z | |
dc.date.available | 2017-03-17T08:30:05Z | |
dc.date.created | 2017-02-19T19:31:45Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Puneet, P. and McGrath, M. and Tay, H. and Al-Riyami, L. and Rzepecka, J. and Moochhala, S. and Pervaiz, S. et al. 2011. The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88. Nature Immunology. 12 (4): pp. 344-353. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/51243 | |
dc.identifier.doi | 10.1038/ni.2004 | |
dc.description.abstract |
Sepsis is one of the most challenging health problems worldwide. Here we found that phagocytes from patients with sepsis had considerable upregulation of Toll-like receptor 4 (TLR4) and TLR2; however, shock-inducing inflammatory responses mediated by these TLRs were inhibited by ES-62, an immunomodulator secreted by the filarial nematode Acanthocheilonema viteae. ES-62 subverted TLR4 signaling to block TLR2- and TLR4-driven inflammatory responses via autophagosome-mediated downregulation of the TLR adaptor-transducer MyD88. In vivo, ES-62 protected mice against endotoxic and polymicrobial septic shock by TLR4-mediated induction of autophagy and was protective even when administered after the induction of sepsis. Given that the treatments for septic shock at present are inadequate, the autophagy-dependent mechanism of action by ES-62 might form the basis for urgently needed therapeutic intervention against this life-threatening condition. © 2011 Nature America, Inc. All rights reserved. | |
dc.publisher | Nature Publishing Group | |
dc.title | The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88 | |
dc.type | Journal Article | |
dcterms.source.volume | 12 | |
dcterms.source.number | 4 | |
dcterms.source.startPage | 344 | |
dcterms.source.endPage | 353 | |
dcterms.source.issn | 1529-2908 | |
dcterms.source.title | Nature Immunology | |
curtin.department | School of Biomedical Sciences | |
curtin.accessStatus | Fulltext not available |
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