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    The Wnt signaling pathways and cell adhesion

    Access Status
    Fulltext not available
    Authors
    Amin, N.
    Vincan, Elizabeth
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Amin, N. and Vincan, E. 2012. The Wnt signaling pathways and cell adhesion. Frontiers in Bioscience. 17 (2): pp. 784-804.
    Source Title
    Frontiers in Bioscience
    DOI
    10.2741/3957
    ISSN
    1093-9946
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/5547
    Collection
    • Curtin Research Publications
    Abstract

    In multicellular organisms, the processes of tissue and organ formation are governed by morphogenetic signaling pathways. The Wnt pathways regulate morphogenesis by controlling cell adhesion and migration; processes that when corrupted, lead to tumorgenesis. It is well known that the Wnt signaling pathways affect adhesion and migration via downstream effectors. Canonical Wnt signaling regulates cell adhesion by regulating the stability of beta-Catenin, a component of the adherens junction. Whereas, non-canonical signaling modulates cytoskeletal dynamics by regulating the activity of downstream effectors that function to organize the cytoskeleton. Recent studies have uncovered a multitude of points of crosstalk between the Wnt pathways and the mechanisms that control cellular architecture, from the level of receptors to the level of transcription. At the same time, cellular mechanisms that are responsible for the regulation of adhesion and migration also function to modulate the activity of several Wnt pathway components. Uncovering these points of crosstalk may lead to better understanding and treatment of the processes that can lead to tumorgenesis.

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