Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Application of a dense gas technique for sterilizing soft biomaterials

    Access Status
    Fulltext not available
    Authors
    Karajanagi, S.
    Yoganathan, R.
    Mammucari, R.
    Park, H.
    Cox, J.
    Zeitels, S.
    Langer, R.
    Foster, Neil
    Date
    2011
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Karajanagi, S. and Yoganathan, R. and Mammucari, R. and Park, H. and Cox, J. and Zeitels, S. and Langer, R. et al. 2011. Application of a dense gas technique for sterilizing soft biomaterials. Biotechnology and Bioengineering. 108 (7): pp. 1716-1725.
    Source Title
    Biotechnology and Bioengineering
    DOI
    10.1002/bit.23105
    ISSN
    0006-3592
    School
    Department of Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/55618
    Collection
    • Curtin Research Publications
    Abstract

    Sterilization of soft biomaterials such as hydrogels is challenging because existing methods such as gamma irradiation, steam sterilization, or ethylene oxide sterilization, while effective at achieving high sterility assurance levels (SAL), may compromise their physicochemical properties and biocompatibility. New methods that effectively sterilize soft biomaterials without compromising their properties are therefore required. In this report, a dense-carbon dioxide (CO 2 )-based technique was used to sterilize soft polyethylene glycol (PEG)-based hydrogels while retaining their structure and physicochemical properties. Conventional sterilization methods such as gamma irradiation and steam sterilization severely compromised the structure of the hydrogels. PEG hydrogels with high water content and low elastic shear modulus (a measure of stiffness) were deliberately inoculated with bacteria and spores and then subjected to dense CO 2 . The dense CO 2 -based methods effectively sterilized the hydrogels achieving a SAL of 10 -7 without compromising the viscoelastic properties, pH, water-content, and structure of the gels. Furthermore, dense CO 2 -treated gels were biocompatible and non-toxic when implanted subcutaneously in ferrets. The application of novel dense CO 2 -based methods to sterilize soft biomaterials has implications in developing safe sterilization methods for soft biomedical implants such as dermal fillers and viscosupplements. © 2011 Wiley Periodicals, Inc.

    Related items

    Showing items related by title, author, creator and subject.

    • Synthesis and evaluation of porous composite hydrogels for tissue engineering applications
      Li, Chao (2012)
      The purpose of this dissertation was to synthesize and evaluate porous poly(2- hydroxyethyl methacrylate) (PHEMA) and PHEMA composite hydrogels containing various concentrations of titanium dioxide (TiO2) nanoparticles, ...
    • Collagen modified porous pHEMA–TiO2 composite hydrogels for tissue engineering
      Li, Chao; Liu, S.; Zheng, Y.; Lou, Xia (2013)
      Poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels are well known for their applications as vision correction devices including contact lenses and intraocular lenses. Like most other synthetic hydrogels, pHEMA is bio-inert ...
    • Effect of strain rate and temperature on elastic properties of PCL/starch
      Nor, F.; Lee, H.; Lim, J.; Kurniawan, Denni (2012)
      Biomaterials for tissue engineering scaffolds are subjected to loading at various strain rates at body temperature. Polymeric based biomaterials used for this purpose often have low melting temperature, potentially ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.