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    Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders

    255973.pdf (527.1Kb)
    Access Status
    Open access
    Authors
    Fitzgerald, Melinda
    Hodgetts, S.
    Van Den Heuvel, C.
    Natoli, R.
    Hart, N.
    Valter, K.
    Harvey, A.
    Vink, R.
    Provis, J.
    Dunlop, S.
    Date
    2013
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Fitzgerald, M. and Hodgetts, S. and Van Den Heuvel, C. and Natoli, R. and Hart, N. and Valter, K. and Harvey, A. et al. 2013. Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders. Reviews in the Neurosciences. 24 (2): pp. 205-226.
    Source Title
    Reviews in the Neurosciences
    DOI
    10.1515/revneuro-2012-0086
    ISSN
    0334-1763
    School
    Health Sciences Research and Graduate Studies
    Remarks

    The final publication is available at www.degruyter.com

    URI
    http://hdl.handle.net/20.500.11937/56909
    Collection
    • Curtin Research Publications
    Abstract

    Irradiation in the red/near-infrared spectrum (R/NIR, 630 -1000 nm) has been used to treat a wide range of clinical conditions, including disorders of the central nervous system (CNS), with several clinical trials currently underway for stroke and macular degeneration. However, R/NIR irradiation therapy (R/NIR-IT) has not been widely adopted in clinical practice for CNS injury or disease for a number of reasons, which include the following. The mechanism/s of action and implications of penetration have not been thoroughly addressed. The large range of treatment intensities, wavelengths and devices that have been assessed make comparisons difficult, and a consensus paradigm for treatment has not yet emerged. Furthermore, the lack of consistent positive outcomes in randomised controlled trials, perhaps due to sub-optimal treatment regimens, has contributed to scepticism. This review provides a balanced précis of outcomes described in the literature regarding treatment modalities and efficacy of R/NIR-IT for injury and disease in the CNS. We have addressed the important issues of specification of treatment parameters, penetration of R/NIR irradiation to CNS tissues and mechanism/s, and provided the necessary detail to demonstrate the potential of R/NIR-IT for the treatment of retinal degeneration, damage to white matter tracts of the CNS, stroke and Parkinson's disease.

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