Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders
MetadataShow full item record
The final publication is available at www.degruyter.com
Irradiation in the red/near-infrared spectrum (R/NIR, 630 -1000 nm) has been used to treat a wide range of clinical conditions, including disorders of the central nervous system (CNS), with several clinical trials currently underway for stroke and macular degeneration. However, R/NIR irradiation therapy (R/NIR-IT) has not been widely adopted in clinical practice for CNS injury or disease for a number of reasons, which include the following. The mechanism/s of action and implications of penetration have not been thoroughly addressed. The large range of treatment intensities, wavelengths and devices that have been assessed make comparisons difficult, and a consensus paradigm for treatment has not yet emerged. Furthermore, the lack of consistent positive outcomes in randomised controlled trials, perhaps due to sub-optimal treatment regimens, has contributed to scepticism. This review provides a balanced précis of outcomes described in the literature regarding treatment modalities and efficacy of R/NIR-IT for injury and disease in the CNS. We have addressed the important issues of specification of treatment parameters, penetration of R/NIR irradiation to CNS tissues and mechanism/s, and provided the necessary detail to demonstrate the potential of R/NIR-IT for the treatment of retinal degeneration, damage to white matter tracts of the CNS, stroke and Parkinson's disease.
Showing items related by title, author, creator and subject.
Potential protective effects of ursolic acid against gamma irradiation-induced damage are mediated through the modulation of diverse inflammatory mediatorsWang, H.; Sim, M.; Loke, W.; Chinnathambi, A.; Alharbi, S.; Tang, F.; Sethi, Gautam (2017)© 2017 Wang, Sim, Loke, Chinnathambi, Alharbi, Tang and Sethi. This study was aimed to evaluate the possible protective effects of ursolic acid (UA) against gamma radiation induced damage both in vitro as well as in vivo. ...
Differential effects of 670 and 830 nm red near infrared irradiation therapy: A comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injuryGiacci, M.; Wheeler, L.; Lovett, S.; Dishington, E.; Majda, B.; Bartlett, C.; Thornton, E.; Harford-Wright, E.; Leonard, A.; Vink, R.; Harvey, A.; Provis, J.; Dunlop, S.; Hart, N.; Hodgetts, S.; Natoli, R.; Van Den Heuvel, C.; Fitzgerald, Melinda (2014)Red/near-infrared irradiation therapy (R/NIR-IT) delivered by laser or light-emitting diode (LED) has improved functional outcomes in a range of CNS injuries. However, translation of R/NIR-IT to the clinic for treatment ...
Rembielak, A.; Green, M.; Saleem, A.; Price, Patricia (2016)© 2015 Elsevier Ltd. All rights reserved. Medical imaging techniques are an important element in early detection for many cancers. They are also essential for determining the location, extension and stage of the lesion ...